30432

Dansylcadaverin

BioReagent, suitable for fluorescence, ≥99.0% (HPLC)

• Synonym(e): N-(5-Aminopentyl)-5-dimethylamino-1-naphthalinsulfonamid
• Empirische Formel (Hill-System): C₁₇H₂₅N₃O₂S
• CAS-Nummer: 10121-91-2
• Molekulargewicht: 335.46
• UNSPSC Code: 12352108
• NACRES: NA.32
• PubChem Substance ID: 57648439
• EC Number: 233-326-9
• Beilstein/REAXYS Number: 2951070
• MDL number: MFCD00042704

Eigenschaften

• product line: BioReagent
• Quality Segment: 100
• assay: ≥99.0% (HPLC)
• mp: 137-140 °C
• fluorescence: λ_ex 335 nm; λ_em 518 nm in methanol, λ_ex 338 nm; λ_em 500 nm (Reaction product)
• suitability: suitable for fluorescence
• storage temp.: −20°C
• SMILES string: CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
• InChI: 1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
• InChI key: MLEBFEHOJICQQS-UHFFFAOYSA-N

Beschreibung

Application

Dansylcadaverine (MDC), an autofluorescent dye, is used to monitor autophagy. MDC accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Biochem/physiol Actions

Der autofluoreszierende Farbstoff Dansylcadaverin, oder Monodansylcadaverin (MDC), wird häufig verwendet, um Autophagie zu überwachen. MDC wird, durch eine Kombination von Ionenfallen und spezifische Wechselwirkungen mit Membranlipiden, bevorzugt in autophagischen Vakuolen anreichert.

Inhibitor of the fibrin-stabilizing factor[1]; Inhibitor of epidermal growth factor (EGF) internalisation[2]; Fluorescent substrate for the assay of transamidating enzymes[3][4]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

air sensitive, handled under inert gas

Other Notes

Die Löslichkeit von Dansylcadaverin wird in Methanol getestet (10 mg/mL). Es ist bekannt, dass Dansylcadaverin auch in DMSO und Essigsäure löslich ist.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves