This product is not cell culture tested or use-tested. Please consider Product C1832 which is suitability tested; it is use-tested for its ability to inhibit the synthesis (that is, suppress the expression) of Interleukin-2 (IL-2) in cultured Jurkat cells.
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30024
Cyclosporin A
97.0-101.5% (on dried basis)
Synonym(e):
Antibiotic S 7481F1
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
25 mg | Warenkorb auf Verfügbarkeit prüfen | € 122,00 |
100 mg | Warenkorb auf Verfügbarkeit prüfen | € 351,00 € 298,35 |
Über diesen Artikel
Empirische Formel (Hill-System):
C62H111N11O12
CAS-Nummer:
Molekulargewicht:
1202.61
UNSPSC Code:
51102829
NACRES:
NA.76
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3647785
Technischer Dienst
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Unterstützung erhaltenQuality Segment
assay
97.0-101.5% (on dried basis)
form
powder
color
white to off-white
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
2-8°C
SMILES string
CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InChI
1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
InChI key
PMATZTZNYRCHOR-CGLBZJNRSA-N
Gene Information
human ... PPIA(5478)
General description
Chemische Struktur: Peptid
Biochem/physiol Actions
Ein Pilzmetabolit mit wirksamen immunsuppressiven Eigenschaften. Er hemmt die T-Zell-Rezeptor-Signaltransduktion über die Bildung eines Cyclosporin A−Cyclophilin Komplexes, der Calcineurin (Protein Phosphatase 2B) inhibiert. Hemmt die durch Interleukin 1?, Lipopolysaccharide und TNF induzierte Stickoxid-Synthese. Kann die Freisetzung von Cytochrom c aus Mitochondrien blockieren.
Leistungsstarkes Immunsuppressivum; hemmt durch Interleukin 1α, Lipopolysaccharide und TNFα induzierte Stickstoffoxidsynthese; Hemmt die Cytochrom c-Freigesetzung aus Mitochondrien.
Packaging
Bodenlose Glasflasche. Der Inhalt befindet sich innerhalb des eingeschobenen Schmelzkegels.
Other Notes
Behälter dicht verschlossen an einem trockenen und gut gelüfteten Ort aufbewahren. An einem trockenen Ort aufbewahren. Lagerklasse (TRGS 510): Nicht brennbare, akut giftige Kat.3 / giftige Schadstoffe, die chronische Wirkungen verursachen.
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Dieser Artikel | |||
|---|---|---|---|
| description 97.0-101.5% (on dried basis) | description BioReagent, from Tolypocladium inflatum, Molecular Biology, ≥95% | description VETRANAL®, analytical standard | description Pharmaceutical Secondary Standard; Certified Reference Material |
| antibiotic activity spectrum fungi | antibiotic activity spectrum fungi | antibiotic activity spectrum - | antibiotic activity spectrum - |
| mode of action enzyme | inhibits | mode of action enzyme | inhibits | mode of action - | mode of action - |
| Quality Level 200 | Quality Level 300 | Quality Level 100 | Quality Level 300 |
| form powder | form powder | form - | form - |
| assay 97.0-101.5% (on dried basis) | assay ≥95% | assay - | assay - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - | storage temp. -10 to -25°C |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Is this product suitable for culture?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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What do you use to reconstitute cyclosporine? Ethanol or DMSO?
1 answer-
This product can be reconstituted in the following:
Dichloromethane: 10 mg/mL
Ethanol: 10 mg/mL
DMSO: 50 mg/mL
Chloroform: 6 mg/mL
H2O: insolubleSolutions may be stored at -20 °C protected from light.
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