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32425

Cyclosporin A

VETRANAL®, analytical standard

Synonym(e):

Antibiotic S 7481F1

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Ihnen/SKUVerfügbarkeitPreis
100 mg
Warenkorb auf Verfügbarkeit prüfen
€ 281,00

Über diesen Artikel

Empirische Formel (Hill-System):
C62H111N11O12
CAS-Nummer:
59865-13-3
Molekulargewicht:
1202.61
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754203
MDL number:
MFCD00274558
Beilstein/REAXYS Number:
3647785

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Unterstützung erhalten

grade

analytical standard

Quality Segment

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChI key

PMATZTZNYRCHOR-CGLBZJNRSA-N

Gene Information

human ... PPIA(5478)

General description

Cyclosporin A (CsA) is a fungal metabolite, a cyclic undecapeptide. It has highly specific immunosuppressive effects with low myelotoxicity, thereby making it a valuable drug in human organ transplantation. Its immunosuppressive activity is based upon its ability to inhibit early steps of T-lymphocyte activation such as lymphokine gene transcription.[1]
Cyclosporin A has been used to:
  • Prevent rejection of kidney and liver transplants.[1]
  • In graft versus host disease.[1]
  • Treatment of autoimmune diseases.[1]
  • Treatment of Schistosomiasis.[1]

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Ein Pilzmetabolit mit wirksamen immunsuppressiven Eigenschaften. Er hemmt die T-Zell-Rezeptor-Signaltransduktion über die Bildung eines Cyclosporin A−Cyclophilin Komplexes, der Calcineurin (Protein Phosphatase 2B) inhibiert. Hemmt die durch Interleukin 1?, Lipopolysaccharide und TNF induzierte Stickoxid-Synthese. Kann die Freisetzung von Cytochrom c aus Mitochondrien blockieren.
Leistungsstarkes Immunsuppressivum; hemmt durch Interleukin 1α, Lipopolysaccharide und TNFα induzierte Stickstoffoxidsynthese; Hemmt die Cytochrom c-Freigesetzung aus Mitochondrien.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Dieser Artikel
PHR1092C18321158504
Cyclosporin A VETRANAL®, analytical standard

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32425

Cyclosporin A

Cyclosporin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

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Cyclosporin

Cyclosporin A from Tolypocladium inflatum, BioReagent, Molecular Biology, ≥95%

Sigma-Aldrich

C1832

Cyclosporin A

Cyclosporin United States Pharmacopeia (USP) Reference Standard

USP

1158504

Cyclosporin

grade

analytical standard

grade

certified reference material, pharmaceutical secondary standard

grade

Molecular Biology

grade

pharmaceutical primary standard

format

neat

format

neat

format

-

format

neat

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

drug transporter assay: suitable

technique(s)

-

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

Quality Level

100

Quality Level

300

Quality Level

300

Quality Level

-

Gene Information

human ... PPIA(5478)

Gene Information

human ... PPIA(5478)

Gene Information

human ... PPIA(5478)

Gene Information

human ... PPIA(5478)

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Analysenzertifikate (COA)

Lot/Batch Number

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Questions

  1. Hello, I got this product from you and wanted to confirm if you have any data regarding its stability after being aliquoted in DMSO and stored at -20ºC or any kind of other storage that you suggest. Thank you,

    1 answer

    1. Stock solutions in ethanol or DMSO should be stored at -20 °C. Cyclosporin is stable in solution if protected from light, but its concentration may drop due to adsorption to the container walls. There is no information on how long Cyclosporin A can be stored in solution.

      Online sources suggest storing solutions at -20°C for up to 3 months.

      Helpful?

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