17936

1α,25-Dihydroxyvitamin D₃

≥97.0% (HPLC)

• Synonym(e): 1α,25-Dihydroxycholecalciferol, Calcitriol
• Empirische Formel (Hill-System): C₂₇H₄₄O₃
• CAS-Nummer: 32222-06-3
• Molekulargewicht: 416.64
• NACRES: NA.79
• PubChem Substance ID: 57647688
• eCl@ss: 34058003
• UNSPSC Code: 12352205
• EC Number: 250-963-8
• MDL number: MFCD00867079
• Beilstein/REAXYS Number: 7559394

Eigenschaften

• Quality Segment: 200
• assay: ≥97.0% (HPLC)
• form: crystals
• color: white to off-white
• storage temp.: −70°C
• SMILES string: [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
• InChI: 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
• InChI key: GMRQFYUYWCNGIN-NKMMMXOESA-N
• Gene Information: human ... VDR(7421)

Beschreibung

General description

1α,25-Dihydroxyvitamin D₃, also referred as calcitriol, is a calcitrophic hormone. It is the most biologically active metabolite of vitamin D produced in proximal tubular cells in the kidney.

Application

1α,25-Dihydroxyvitamin D₃ has been used to study its effect on transplantation success of human muscle precursor cells (hMPCs) in severe combined immunodeficient (SCID) mice in-vitro.

Biochem/physiol Actions

Biologisch aktive Form von Vitamin D₃ bei der Calciumaufnahme und Ablagerung.

Biologisch aktive Form von Vitamin D₃ bei der Calciumaufnahme und Ablagerung. 1α,25-Dihydroxyvitamin D₃ hat vielfältige Auswirkungen auf die zelluläre Differenzierung und Proliferation und kann die Immunantwort und Funktion des zentralen Nervensystems modulieren. Neuere Studien legen nahe, dass 1α,25-Dihydroxyvitamin D ₃ als chemopräventives Mittel gegen verschiedene Malignome, einschließlich Krebserkrankungen der Prostata und des Dickdarms, wirkt und Synergien mit anderen Krebsmedikamenten eingeht.

1α,25-Dihydroxyvitamin D₃ modulates energy metabolism by facilitating various metabolic processes, such as Ca²⁺ signaling and modulation of glucocorticoids, by affecting adipocyte apoptosis and by regulating the expression and production of multiple cytokines. In addition, it also modulates phosphorus homeostasis through actions in the intestine, kidney and bone. 1α,25-Dihydroxyvitamin D₃ exhibits antiproliferative effects and is used as a potent therapeutic for human prostate cancer.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Sicherheitshinweise

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H310 + H330,H372
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
• pcodes: P260 - P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral