PHR8775

Methylnaltrexon

certified reference material, pharmaceutical secondary standard

• Synonym(e): (17RS)-17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinaniumbromid, N-Methylnaltrexon, MNTX, Methylnaltrexon, Mrz-2663, Naltrexon-Methobromid, Quartäres Ammoniumderivat von Naltrexon
• Empirische Formel (Hill-System): C₂₁H₂₆NO₄ · Br
• CAS-Nummer: 73232-52-7
• Molekulargewicht: 436.34
• UNSPSC Code: 41116107
• NACRES: NA.24
• MDL number: MFCD06407831

Eigenschaften

• Quality Segment: 300
• grade: certified reference material, pharmaceutical secondary standard
• agency: traceable to USP 1430735
• API family: methylnaltrexone, naltrexone
• CofA: current certificate can be downloaded
• packaging: pkg of 200 mg
• application(s): pharmaceutical
• SMILES string: [Br-].C[N@+]1(CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@]2(O)CCC4=O)c35)CC6CC6
• InChI: 1S/C21H25NO4.BrH/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13;/h4-5,12,16,19,25H,2-3,6-11H2,1H3;1H/t16-,19+,20+,21-,22?;/m1./s1
• InChI key: IFGIYSGOEZJNBE-KNLJMPJLSA-N

Beschreibung

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Methylnaltrexonbromid ist ein narkotischer Antagonist.

Methylnaltrexonbromid ist ein narkotischer Antagonist. Es ist ein peripher wirkender μ-Opioidrezeptor-Antagonist, der die Blut-Hirn-Schranke nicht überqueren kann. Es reversiert viele Nebenwirkungen von Opioiden, ohne die Schmerzlinderung zu beeinflussen.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Warning
• Gefahrencodes: H371
• Sicherheitshinweise: P260 - P264 - P270 - P308 + P311 - P405 - P501
• Hazard Classifications: STOT SE 2 Oral
• Zielorgane: Gastrointestinal tract
• Lagerklasse: 13 - Non Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable