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PHR1078

Supelco

Phytonadion

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

Vitamin K1, Phytomenadion, 2-Methyl-3-phytyl-1,4-naphthochinon, 3-Phytylmenadion, Phyllochinon, Vitamin K1(20)

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About This Item

Empirische Formel (Hill-System):
C31H46O2
CAS-Nummer:
Molekulargewicht:
450.70
Beilstein:
2568816
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to BP 423
traceable to Ph. Eur. P1609000
traceable to USP 1538006

API-Familie

phytonadione

Analysenzertifikat (CofA)

current certificate can be downloaded

Lagerbedingungen

protect from light

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Brechungsindex

n20/D 1.527 (lit.)

mp (Schmelzpunkt)

−20 °C (lit.)

Dichte

0.984 g/mL at 25 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O

InChI

1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1

InChIKey

MBWXNTAXLNYFJB-NKFFZRIASA-N

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Allgemeine Beschreibung

Phytonadione belongs to the category of oral anticonvulsant drugs. It protects a newborn from acquiring hemorrhagic diseases by maintaining a normal blood clotting mechanism.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

Phytonadione may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

Die Werte der Analyten sind Lot-spezifisch.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAB3714 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Analysenzertifikate (COA)

Lot/Batch Number

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

NP-HPLC method for determining phytonadione and its impurities
Xue M, et al.
Journal of Liquid Chromatography and Related Technologies, 39(17-18), 799-805 (2016)
Comparison of oral vs intravenous phytonadione (vitamin K1) in patients with excessive anticoagulation: a prospective randomized controlled study
Lubetsky A, et al.
Archives of Internal Medicine, 163(20), 2469-2473 (2003)
Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis
DeZee KJ, et al.
Archives of Internal Medicine, 166(4), 391-397 (2006)
Development and validation of spectrophotometric methods fordetermination of phytomenadione in injection
Patel SA and Parikh PK
Current Research in Pharmaceutical Sciences, 39(17-18), 26-30 (2012)
M Kyla Shea et al.
The American journal of clinical nutrition, 98(1), 197-208 (2013-05-31)
Animal studies have shown that vitamin K treatment reduced vascular calcification, but human data are limited. We determined the association between vitamin K status and coronary artery calcium (CAC) progression in the Multi-Ethnic Study of Atherosclerosis by using a case-cohort

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