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12070

Sigma-Aldrich

Benzamid

purum, ≥98.0% (HPLC)

Synonym(e):

Benzoesäureamid

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About This Item

Lineare Formel:
C6H5CONH2
CAS-Nummer:
55-21-0
Molekulargewicht:
121.14
Beilstein:
385876
EG-Nummer:
200-227-7
MDL-Nummer:
MFCD00007968
UNSPSC-Code:
12352100
PubChem Substanz-ID:
329749611

Qualität

purum

Assay

≥98.0% (HPLC)

mp (Schmelzpunkt)

125-128 °C (lit.)
125-128 °C

Löslichkeit

methanol: soluble 1 g/10 mL, clear, colorless to faintly yellow

SMILES String

NC(=O)c1ccccc1

InChI

1S/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)

InChIKey

KXDAEFPNCMNJSK-UHFFFAOYSA-N

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Anwendung

Benzamide was used to study the effect of inhibitors of endonuclease and poly(ADP ribose) polymerase on anti-Fas monoclonal antibody treated Jurkat cells[1].

Biochem./physiol. Wirkung

Inhibiert Poly(ADP-Ribose)-Polymerase (PARP)
Benzamide is a specific inhibitor of poly(ADP-ribose)polymerase[2]. It prevents glutamate- and methamphetamine-induced neurotoxicity in vitro in C57B1/6N mouse[3].

Ersetzt durch

Produkt-Nr.
Beschreibung
Preisangaben

135828

Benzamid, 99%

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Warning

H-Sätze

H302,H341

Gefahreneinstufungen

Acute Tox. 4 Oral - Muta. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

356.0 °F - closed cup

Flammpunkt (°C)

180 °C - closed cup

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Analysenzertifikate (COA)

Lot/Batch Number

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E Kun et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(23), 7219-7223 (1983-12-01)
Human fibroblasts were subjected to nutritionally induced G1 block, followed by release and subsequent entry into S phase, and exposed to nontoxic concentrations of carcinogens in early S phase. Cell transformation occurred as determined by early morphologic cell alterations, anchorage-independent
I Yamadori et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 46(1), 85-90 (1997-12-24)
We compared two methods to stain apoptotic cells, one using terminal deoxynucleotidyl transferase (TDT), the other DNA polymerase I, using leukemia cell lines treated with anti-Fas monoclonal antibody (MAb). Both TDT and polymerase I strongly reacted with fragmented nuclei of
C Cosi et al.
Brain research, 735(2), 343-348 (1996-10-07)
Previous studies have indicated that the activation of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA plasticity-related phenomena, is an early event occurring in glutamate-induced neurotoxicity in vitro, and that inhibitors of PARP, including benzamide, are protective against both glutamate-
James M Wright et al.
The Cochrane database of systematic reviews, 4, CD001841-CD001841 (2018-04-19)
This is the first update of a review published in 2009. Sustained moderate to severe elevations in resting blood pressure leads to a critically important clinical question: What class of drug to use first-line? This review attempted to answer that
Jamin D Steffen et al.
Journal of medicinal chemistry, 54(15), 5403-5413 (2011-06-23)
The metabolism of poly(ADP-ribose) (PAR) in response to DNA strand breaks, which involves the concerted activities of poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribose) glycohydrolase (PARG), modulates cell recovery or cell death depending upon the level of DNA damage. While PARP inhibitors
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