SCC287

SQ-20B Human Squamous Cell Carcinoma Cell Line

SQ-20B human squamous cell carcinoma cell line is a widely used model for radiation-resistant HNSCC.

• NACRES: NA.81
• UNSPSC Code: 41106514

Eigenschaften

• application(s): cell analysis

Beschreibung

General description

Squamous cell carcinoma of the head and neck (HNSCC) represents 90% of all head and neck cancers (1). HNSCC is the 9th-most common cancer worldwide and is characterized by a high rate of recurrence after therapy, with a median 5-year survival range of 40-50% (1). Radiation resistance can arise when cells undergo sublethal damage during x-ray treatment, giving rise refractory post-treatment tumors with poor prognosis (2). Cellular models of HNSCC that demonstrate radiation-resistance are critical for elucidating factor associated with radio-resistance and advancing effective therapies.

The SQ-20B human laryngeal squamous cell carcinoma cell line is a widely used model for radiation-resistant HNSCC. SQ-20B cells were derived from a laryngeal tumor (tumor stage 2 node stage 0) that presented following primary radiation therapy (2). The SQ-20B cell line harbors the c-raf proto-oncogene (3) associated with tumorigenicity and radio-resistance (4). SQ-20B cells have been characterized by expression of the SCC marker p63 (p40) (5). The characteristics of the SQ-20B cell line demonstrate its utility as a model for cellular mechanisms that give rise to radiation resistance.

<bold>Source:</bold>
The SQ-20B cell line was derived from a tumor on the larynx of a patient undergoing radiation therapy2 and harbors a male karyotype (3).

Research Category:
Cancer

Biochem/physiol Actions

Human, Cancer Cells

Packaging

&ge;1X10⁶ cells/vial

Preparation Note

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

Subject to local law, this product is intended to be sold for internal in vitro research use only subject to terms and conditions found here: www.sigmaaldrich.com/restrictedcelluse. This product may not be: re-engineered or copied; used to make derivatives, modifications or functional equivalents; used to obtain patents or other IP claiming use of the product; used to develop, test, or manufacturer a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. A license or limited commercial use agreement is required for use by any for-profit entity, use in services, and use in sponsored academic research. For information regarding any such use, please contact licensing@milliporesigma.com.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable