Direkt zum Inhalt
Merck

HNS1MAG-95K

Millipore

MILLIPLEX® Human Neuroscience Magnetic Bead Panel 1 - Neuroscience Multiplex Assay

allows quantitative multiplex detection of multiple analytes simultaneously

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
12161503
eCl@ss:
32161000
NACRES:
NA.47

To order a Milliplex® kit, please search for your analyte of interest.

Qualitätsniveau

Speziesreaktivität

human

Hersteller/Markenname

Milliplex®

assay range

accuracy: 107%
(DJ1)

accuracy: 108%
(a-Synuclein)

accuracy: 123%
(TG2)

standard curve range: 12-50,000 pg/mL
(GFAP)

standard curve range: 15-60,000 pg/mL
(NSE)

standard curve range: 20-80,000 pg/mL
(UCHL1)

standard curve range: 244-1,000,000 pg/mL
(alpha-synuclein)

standard curve range: 61-250,000 pg/mL
(DJ1)

standard curve range: 61-250,000 pg/mL
(TG2)

Methode(n)

multiplexing: suitable

Nachweisverfahren

fluorometric (Luminex xMAP)

Versandbedingung

ambient

Allgemeine Beschreibung

Neurological dysfunction may be initiated by a broad spectrum of diseases, as well as physical injury to the brain or spinal cord. Numerous potential biomarkers of neurological dysfunction have been identified. The ability to perform multiplex analysis of these biomarkers offers a valuable research tool to better understand this area of neuroscience.

MILLIPLEX® Human Neuroscience Bead Panel 1 is a 6-plex kit to be used for the simultaneous quantification of any or all of the following analytes in cerebrospinal fluid (CSF) samples: α-Synuclein, DJ1/PARK7, Glial fibrillary acidic protein (GFAP), Neuron specific enolase (NSE), Transglutaminase 2 (TGM2), and Ubiquitin carboxyl-terminal esterase L1 (UCHL1/PARK5).

Panel Type: Neuroscience

Spezifität

Cross Reactivty
Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.

Anwendung

  • Analytes: GFAP, NSE, α-Synuclein, PARK5, Transglutaminase 2 (TGM2)
  • Recommended Sample type: CSF
  • Recommended Sample dilution: Neat
  • Assay Run Time: Overnight or one day
  • Research Category: Neuroscience

Leistungsmerkmale und Vorteile

Design your multiplex kit by choosing available analytes within this panel.

Verpackung

Everything you need in a single kit.

Lagerung und Haltbarkeit

Recommended storage for kit components is 2 - 8°C.

Sonstige Hinweise

Sensitivity: See protocol for sensitivities of individual analytes

Rechtliche Hinweise

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Daniela Diaz-Lucena et al.
Journal of neurology, 267(9), 2567-2581 (2020-05-07)
Differential diagnosis of neurodegenerative dementia is currently supported by biomarkers including cerebrospinal fluid (CSF) tests. Among them, CSF total-tau (t-tau), phosphorylated tau (p-tau) and β-amyloid42 (Aβ42) are considered core biomarkers of neurodegeneration. In the present work, we hypothesize that simultaneous
Martin Trapecar et al.
Science advances, 7(5) (2021-01-31)
Slow progress in the fight against neurodegenerative diseases (NDs) motivates an urgent need for highly controlled in vitro systems to investigate organ-organ- and organ-immune-specific interactions relevant for disease pathophysiology. Of particular interest is the gut/microbiome-liver-brain axis for parsing out how

Verwandter Inhalt

Learn how to integrate multiplex and high sensitivity immunoassay technology to further neuroscience research with MILLIPLEX® multiplex and Single Molecule Counting (SMC®) high sensitivity immunoassay detection of Alzheimer’s disease (AD) biomarkers in human cerebrospinal fluid, plasma, and serum samples.

Learn how multiplex detection of Alzheimer’s disease biomarkers, using the MILLIPLEX® Human Amyloid Beta and Tau Magnetic Bead Panel, allows for a different perspective on neurodegenerative disease research.

Neuroscience multiplex assays, such as MILLIPLEX® multiplex assays, enable simultaneous measurement of neuroscience-related biomarkers to gain a better picture of neurodegenerative diseases, neurological disorders, and neuropeptide/neurohormone signaling.

Finden Sie Immunassays zur Bestimmung von Zytokinen mit Relevanz auf dem Gebiet der Neuroimmunologie und bei Neuroinflammation sowie von Biomarkern für neurodegenerative Erkrankungen.

Alle anzeigen

Questions

1–2 of 2 Questions  
  1. How can I normalize protein for this test? Just using same volume and total concentration protein are not reliable.

    1 answer
    1. The kit has been verified for use with CSF and cell/tissue culture supernatants. Protein normalization is not required for these sample types. If using the kit with cell or tissue lysates, the sample will need to be normalized to total protein, using either a BCA or Coomassie-based assay. The product has not been validated for use with cell/tissue lysates.

      Helpful?

  2. Can serum or plasma samples be utilized in the Human Neuroscience Panel 1 kit, considering that the protocol exclusively mentions CSF?

    1 answer
    1. The kit has not been validated with serum/plasma samples. Eight normal plasma samples were tested at a 1:4 dilution. It was found that GFAP and UCHL1 will require more sensitivity.

      Helpful?

Reviews

No rating value

Active Filters

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.