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539160

Proteasome Inhibitor I

Name: Proteasome Inhibitor I
Brand: MM

The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(e):

Proteasome Inhibitor I, PSI

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Über diesen Artikel

Empirische Formel (Hill-System):

C₃₂H₅₀N₄O₈

Molekulargewicht:

618.76

NACRES:

NA.77

UNSPSC Code:

12352202

Assay:

≥90% (HPLC)

Form:

solid

Storage condition:

OK to freeze

Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Technischer Dienst

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Eigenschaften

Quality Segment

100

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

DMSO: 30 mg/mL, ethanol: 30 mg/mL, methanol: soluble

shipped in

ambient

storage temp.

−20°C

Beschreibung

General description

A cell-permeable, reversible inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α and Okadaic Acid (Cat. No. 495604) through inhibition of IκB-α degradation. A 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539161) in DMSO is also available.

Cell-permeable inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinylated proteins in neuronal cells. Prevents NF-κB activation in response to TNFα and okadaic acid through inhibition of IκB-α degradation, thereby interfering with induction of iNOS in macrophages.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells

Product does not compete with ATP.

Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.

Other Notes

Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 3308.
Mori, S., et al. 1995. J. Biol. Chem.270, 29447.
Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578.
Traenckner, E.B., et al. 1994. EMBO J. 13, 5433.

Z-Ile-Glu(OtBu)-Ala-Leu-CHO

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Dieser Artikel	539162	219415	420099
Sigma-Aldrich 539160 Proteasome Inhibitor I	Sigma-Aldrich 539162 Proteasome Inhibitor II	Sigma-Aldrich 219415 Cathepsin-Inhibitor I	Millipore 420099 JAK-Inhibitor I
description The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.	description The Proteasome Inhibitor II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.	description The Cathepsin Inhibitor I controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.	description JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC₅₀ = 15 nM), JAK2 (IC₅₀ = 1 nM), JAK3 (K_i= 5 nM) and Tyk2 (IC₅₀ = 1 nM).
assay ≥90% (HPLC)	assay ≥95% (HPLC)	assay >90% (HPLC)	assay ≥98% (HPLC)
form solid	form lyophilized solid	form solid	form solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. 10-30°C	storage temp. −20°C
storage condition OK to freeze	storage condition desiccated, OK to freeze	storage condition OK to freeze, protect from light, desiccated	storage condition OK to freeze, protect from light

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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