5.08161

SNC80

• Synonym(e): SNC80, δ Opioid Receptor Agonist, SNC80
• Empirische Formel (Hill-System): C₂₈H₃₉N₃O₂
• CAS-Nummer: 156727-74-1
• Molekulargewicht: 449.63
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD00672673
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Eigenschaften

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• potency: 0.32 μM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: cream
• solubility: 1 M HCl: 100 mM, DMSO: 20 mM
• storage temp.: −20°C
• SMILES string: N3([C@H](CN([C@@H](C3)C)CC=C)C)[C@@H](c2cc(ccc2)OC)c1ccc(cc1)C(=O)N(CC)CC
• InChI: 1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
• InChI key: KQWVAUSXZDRQPZ-UMTXDNHDSA-N

Beschreibung

General description

A very potent and selective δ opioid receptor agonist (IC₅₀ = 0.32 µM). Shown to induce dose- and time-dependent antinociception after i.c.v., i.th. and i.p. administration in mice. Widely used in studies of depression and inflammatory injuries. It is also reported to be acted upon heteromeric u-d receptors.

Biochem/physiol Actions

Primary Target
Dela opioid receptor

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pradhan, A., et al., 2013. Mol Pain.9, 8.
Saitoh, A., et al., 2012. Curr. Neuropharmacol.10, 231.
Metcalf. M. et al. 2012. ACS Chem. Neurosci.3, 505.
Bilsky, J., et al. 1995. J. Pharmacol. Exp. Ther.273, 359.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable