506158

p38 MAP Kinase Inhibitor VII, SD-169

The p38 MAP Kinase Inhibitor VII, SD-169, also referenced under CAS 1670-87-7, controls the biological activity of p38 MAP Kinase.

• Synonym(e): p38 MAP Kinase Inhibitor VII, SD-169, Indole-5-carboxamide
• Empirische Formel (Hill-System): C₉H₈N₂O
• CAS-Nummer: 1670-87-7
• Molekulargewicht: 160.17
• MDL-Nummer: MFCD07779486
• UNSPSC-Code: 51111800
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: off-white
• Löslichkeit: water: 1 mg/mL; DMSO: 10 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• InChI: 1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12)
• InChIKey: GQMYQEAXTITUAE-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC₅₀ = 3.2 nM). It inhibits p38β only at much higher concentrations (IC₅₀ = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Harmful (C)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

Medicherla, S., et al. 2006. J. Pharmacol. Exp. Ther.318, 99.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable