5.05877

(S)-(-)-Raclopride

• Synonym(e): (S)-(-)-Raclopride, Dopamine Receptor D2 Antagonist, (S)-Raclopride, Raclopride
• Empirische Formel (Hill-System): C₁₅H₂₀Cl₂N₂O₃
• CAS-Nummer: 84225-95-6
• Molekulargewicht: 347.24
• MDL number: MFCD02179386
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• assay: ≥98% (HPLC)
• Quality Segment: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 100 mM, ethanol: 25 mM
• storage temp.: 2-8°C
• SMILES string: Clc1c(c(c(c(c1)Cl)O)C(=O)NC[C@@H]2N(CCC2)CC)OC
• InChI: 1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m1/s1
• InChI key: WAOQONBSWFLFPE-SECBINFHSA-N

Beschreibung

General description

D₂-like dopamine receptor antagonist targeting D₂R (pKi =8.0), D₃R (pKi = 7.9), and 5-HT1A R (pKi=5.2). Used to explore D₂ like receptor mediated effects in neuropathic pain, and in antagonism studies of DA receptors during heroin usage and cocaine. D₂ Receptor selectivity in various preps shows IC₅₀ values around 32 nM.

Biochem/physiol Actions

Reversible: yes

Other Notes

Dang, Y. H. et al. 2010. Neurosci.169, 1872.

Platt, D. M. et al. 2010. J. Pharmacol. Exp. Ther.332, 985.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable