MABN53

Anti-Dopamine D2 receptor (DRD2) Antibody, clone 2B9

clone 3D9, from mouse

• Synonym(e): Dopamine D2 receptor
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: 3D9, monoclonal
• Application: ICC, WB
• Citations: 12

Eigenschaften

• biological source: mouse
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: 3D9, monoclonal
• species reactivity: rat
• species reactivity (predicted by homology): human (immunogen homology)
• technique(s): immunocytochemistry: suitable, western blot: suitable
• isotype: IgMκ
• NCBI accession no.: NP_000786
• UniProt accession no.: P14416
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... DRD2(1813) ; rat ... Drd2(24318)

Beschreibung

General description

Problems in the CNS dopaminergic system are thought to be the root cause of some neuropsychiatric disorders. Dopamine D2 receptor is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Dopamine D2 receptor signaling using Nurr1 and ERK may play an important role in mesencephalic dopaminergic neuronal development. Faulty D2 receptors have been common in cases of ROS-dependent hypertension. In addition, defects in DRD2 are associted with alcohol-responsive dystonia, varying susceptability to familial alcoholism as well as a contributing factor to the suicide risk in alcoholics.

~50 kDa observed

Immunogen

Linear peptide corresponding to human Dopamine D2 receptor.

Application

Immunocytochemistry Analysis: A previous lot was used by an independent laboratory to detect Dopamine D2 receptor in Ntera-2 cells and in rat brain neurons. Courtesy of Glenn Morris, Wolfson Centre for Inherited Neuromuscular Disease.

This Anti-Dopamine D2 receptor (DRD2) Antibody, clone 2B9 is validated for use in WB, IC for the detection of Dopamine D2 receptor (DRD2).

Physical form

Format: Purified

Analysis Note

Control
Rat spinal cord tissue lysate

Evaluated by Western Blot in rat spinal cord tissue lysate.

Western Blot Analysis: 5 µg/mL of this antibody detected Dopamine D2 receptor on 10 µg of rat spinal cord tissue lysate.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• wgk: WGK 1