310500
D-erythro-Sphingosin, N,N-Dimethyl-
A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 µM) and stimulates Src kinase activity.
Synonym(e):
D-erythro-Sphingosin, N,N-Dimethyl-, DMS, SK-Inhibitor III, Sphingosin-Kinase-Inhibitor III
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Über diesen Artikel
Quality Segment
assay
≥98% (TLC)
form
oil (Clear), waxy solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
DMSO: 5 mg/mL, ethanol: soluble, methanol: soluble
shipped in
ambient
storage temp.
−20°C
SMILES string
N([C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO)(C)C
InChI
1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1
InChI key
YRXOQXUDKDCXME-YIVRLKKSSA-N
General description
Biochem/physiol Actions
PKC
Preparation Note
Other Notes
Ohta, H., et al. 1995. Cancer Res.55, 691.
Kimura, S., et al. 1992. Biochem. Pharmacol.44, 1585.
Hanada, K., et al. 1991. Biochemistry30, 11682.
Igarashi, Y., et al. 1990. J. Biol. Chem.265, 5385.
Legal Information
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Dieser Artikel | |||
|---|---|---|---|
| description A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 µM) and stimulates Src kinase activity. | description N,N-dimethyl-D-erythro-sphingosine, neat oil | description Biologically active, cell-permeable, non-physiological ceramide analog. | description The Sphingosine Kinase Inhibitor, also referenced under CAS 1177741-83-1, controls the biological activity of Sphingosine Kinase. This small molecule/inhibitor is primarily used for Cell Signaling applications. |
| form waxy solid, oil (Clear) | form liquid | form solid | form solid |
| assay ≥98% (TLC) | assay >99% (TLC) | assay ≥98% (TLC) | assay ≥98% (HPLC) |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Avanti Research™ - A Croda Brand 860496O | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility DMSO: 5 mg/mL, ethanol: soluble, methanol: soluble | solubility - | solubility DMSO: 25 mg/mL, methanol: 5 mg/mL | solubility DMSO: 5 mg/mL |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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