04-959

Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2

clone RORg2, from hamster(Armenian)

• Synonym(e): RAR-related orphan receptor C, RAR-related orphan receptor gamma, retinoic acid-binding receptor gamma, nuclear receptor ROR-gamma, retinoid-related orphan receptor gamma, Nuclear receptor RZR-gamma, RZR-GAMMA, Nuclear receptor subfamily 1 group F member
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: hamster (Armenian)
• Qualitätsniveau: 100
• Antikörperform: purified antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: RORg2, monoclonal
• Speziesreaktivität: mouse
• Methode(n): western blot: suitable
• NCBI-Hinterlegungsnummer: NP_035411
• UniProt-Hinterlegungsnummer: P51450
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: mouse ... Rorc(19885)

Beschreibung

Allgemeine Beschreibung

Retinoid-related orphan receptor-gamma t (RORγT) is one of two RORγ isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORγT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORγT is a requirement for TH17 cell differentiation. Inhibition of RORγT is induced by TGF-β’s interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells.

Immunogen

Epitope: Unknown

Histidine-tagged recombinant protein corresponding to mouse Retinoid-Related Orphan Receptor γ T (RORγT).

Anwendung

Research Category
Entzündung & Immunologie

Research Sub Category
Entzündungs- & Autoimmunmechanismen

Detect Retinoid-Related Orphan Receptor γ T using this Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2 validated for use in WB, FC & IF.

Qualität

Evaluated by Western Blot in EL4 cell lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected Retinoid-Related Orphan Receptor γ T (RORγT) in 10 µg of EL4 cell lysate.

Zielbeschreibung

~52 kDa observed

Physikalische Form

Protein G Purified

Format: Purified

Purified hamster monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
EL4 cell lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable