M-072

Metformin -hydrochlorid -Lösung

Name: Metformin -hydrochlorid -Lösung
Brand: CERILLIAN
Price: 121 EUR

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

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Über diesen Artikel

Empirische Formel (Hill-System):

C₄H₁₂ClN₅

CAS-Nummer:

1115-70-4

Molekulargewicht:

165.62

NACRES:

NA.24

UNSPSC Code:

41116107

EC Number:

200-659-6

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grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike^®/Snap-N-Shoot^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

SMILES string

Cl.CN(C)C(=N)NC(N)=N

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

InChI key

OETHQSJEHLVLGH-UHFFFAOYSA-N

Gene Information

—

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1 of 4

Dieser Artikel	1396309	M0605000	BP227
Supelco M-072 Metformin hydrochloride solution	USP 1396309 Metformin hydrochloride	M0605000 Metformin hydrochloride	BP227 Metformin hydrochloride
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule
technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) -	technique(s) -	technique(s) -
form liquid	form -	form -	form crystalline
Quality Level 300	Quality Level -	Quality Level -	Quality Level -
grade certified reference material	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard
storage temp. −20°C	storage temp. -	storage temp. -	storage temp. 2-8°C

General description

A Snap-N-Spike^® reference solution applicable to use in clinical toxicology by LC-MS/MS or GC/MS. Metformin is an antidiabetic drug which functions by suppressing liver production of glucose. This biguanide analog is used specifically for treatment of type 2 diabetes.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

pictograms

GHS02,GHS06,GHS08

signalword

Danger

hcodes

H225,H301 + H311 + H331,H370

pcodes

P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Lagerklasse

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Zulassungslistungen

Zulassungslistungen werden hauptsächlich für chemische Produkte erstellt. Für nicht-chemische Produkte können hier nur begrenzte Angaben gemacht werden. Kein Eintrag bedeutet, dass keine der Komponenten gelistet ist. Es liegt in der Verantwortung des Benutzers, die sichere und legale Verwendung des Produkts zu gewährleisten.

67-56-1

CAS No.

rmu

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Metformin increases blood flow and forearm glucose uptake in a group of non-obese type 2 diabetes patients.

F O Magalhães et al.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 38(8), 513-517 (2006-08-31)

The present study was designed to determine the effects of metformin on the forearm glucose uptake and blood flow after an oral glucose challenge. Eleven normal subjects, and ten non-obese type 2 diabetes patients without medication of anti-hyperglycemic drug and

Transfer of metformin into human milk.

T W Hale et al.

Diabetologia, 45(11), 1509-1514 (2002-11-19)

The aim of this study was to characterize the milk-to-plasma ratio and infant dose for metformin in breastfeeding women, and to measure plasma concentrations and assess any effects in their infants. We hypothesized that metformin used by mothers is safe

Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: a randomized, placebo-controlled study. The Pioglitazone 027 Study Group.

D Einhorn et al.

Clinical therapeutics, 22(12), 1395-1409 (2001-02-24)

Their complimentary mechanisms of action suggest that a combination of pioglitazone hydrochloride and metformin may have clinically beneficial effects in the treatment of patients with type 2 diabetes. This study was undertaken to assess the efficacy and tolerability of pioglitazone

Effects of metformin on bile salt transport by monolayers of human intestinal Caco-2 cells.

D Carter et al.

Diabetes, obesity & metabolism, 4(6), 424-427 (2002-10-31)

The antidiabetic biguanide metformin has been shown to increase faecal excretion of bile salts in type 2 diabetes. Cultured human intestinal Caco-2 cell monolayers provide a model of human enterocytes. These monolayers are used here to determine the effect of

Comparison of peripheral metabolic effects of insulin and metformin following severe burn injury.

Dennis C Gore et al.

The Journal of trauma, 59(2), 316-322 (2005-11-19)

Both insulin and metformin have been shown to attenuate hyperglycemia and reduce net muscle protein catabolism following burn injury. The purpose of this study was to compare the peripheral metabolic effects of insulin and metformin in severe burn patients. Six

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Global Trade Item Number

SKU	GTIN
M-072-1ML	04061833976470

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