L-021

Lorazepam-Glucuronid -Lösung

Name: Lorazepam-Glucuronid -Lösung
Brand: CERILLIAN

100 μg/mL in acetonitrile: water (1:1), ampule of 1 mL, certified reference material, Cerilliant^®

Slide 1 of 1

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Größe auswählen

Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Über diesen Artikel

Empirische Formel (Hill-System):

C₂₁H₁₈Cl₂N₂O₈

CAS-Nummer:

32781-79-6

Molekulargewicht:

497.28

NACRES:

NA.24

PubChem Substance ID:

329817344

UNSPSC Code:

41116107

MDL number:

MFCD02682126

Wichtige Dokumente

Gesamtdokumentation anzeigen

Fortfahren mit

Technischer Dienst

Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.

Unterstützung erhalten

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike^®/Snap-N-Shoot^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

drug control

Narcotic Licence Schedule B (Switzerland)

concentration

100 μg/mL in acetonitrile: water (1:1)

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

O[C@@H]1[C@@H](O)[C@H](OC2N=C(c3ccccc3Cl)c4cc(Cl)ccc4NC2=O)O[C@@H]([C@H]1O)C(O)=O

InChI

1S/C21H18Cl2N2O8/c22-8-5-6-12-10(7-8)13(9-3-1-2-4-11(9)23)25-19(18(29)24-12)33-21-16(28)14(26)15(27)17(32-21)20(30)31/h1-7,14-17,19,21,26-28H,(H,24,29)(H,30,31)/t14-,15-,16+,17-,19?,21-/m0/s1

InChI key

IWOJSSFCRQKNKN-IFBJMGMISA-N

General description

Lorazepam glucuronide is a primary urinary metabolite of lorazepam, a benzodiazepine often prescribed for treatment of anxiety disorders. This Certified Spiking Solution^® is suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from clinical toxicology and forensic analysis to urine drug testing.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

B-033

Benzodiazepine Multi-component Mixture-8 solution, 250 μg/mL each component in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

L-901

Lorazepam solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

L-902

Lorazepam-d₄ solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

L-907

Lormetazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

L-911

Lorazepam-d₄ solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

D-163

Delorazepam-D₄ solution, 100 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant^®

L-059

Lorazepam-D₄ glucuronide lithium salt solution, 100 μg/mL (Acetonitrile:Water (50:50) (v/v), (as free acid)), certified reference material, ampule of 1 mL, Cerilliant^®

pictograms

GHS02,GHS07

signalword

Danger

hcodes

H225,H302,H319

pcodes

P210 - P233 - P240 - P241 - P301 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Lagerklasse

3 - Flammable liquids

wgk

WGK 2

flash_point_f

55.4 °F - closed cup

flash_point_c

13 °C - closed cup

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration.

Eleonora L Swart et al.

American journal of kidney diseases : the official journal of the National Kidney Foundation, 45(2), 360-371 (2005-02-03)

The objective is to study the population pharmacokinetics of lorazepam and midazolam in critically ill patients with acute renal failure who are treated with continuous venovenous hemofiltration (CVVH). Twenty critically ill patients with acute renal failure on CVVH therapy were

Effect of renal impairment and hemodialysis on lorazepam kinetics.

G Morrison et al.

Clinical pharmacology and therapeutics, 35(5), 646-652 (1984-05-01)

The effect of renal disease on lorazepam kinetics was assessed in three groups: six normal subjects, six patients with renal impairment, and four functionally anephric patients. Subjects received single 1.5- or 3-mg intravenous and oral doses; eight subjects (four normal

Inhibition of acetaminophen and lorazepam glucuronidation in vitro by probenecid.

L L von Moltke et al.

Biopharmaceutics & drug disposition, 14(2), 119-130 (1993-03-01)

The effect of probenecid on glucuronidation of acetaminophen and lorazepam in hepatic microsomes from various species was studied to see if in vitro results were consistent with previous in vivo observations. Mouse, rat, and human microsomes were incubated with acetaminophen

Identification of lorazepam and sildenafil as examples for the application of LC/ionspray-MS and MS-MS with mass spectra library searching in forensic toxicology.

W Weinmann et al.

Forensic science international, 113(1-3), 339-344 (2000-09-09)

A mass spectra (MS) library using in-source collision induced dissociation (ESI-CID) as well as a tandem-mass spectra (MS-MS) library with product ion spectra of drugs has recently been developed with a triple-quadrupole ionspray mass spectrometer [1,2]. For the ESI-CID MS

Kinetic disposition of lorazepam with focus on the glucuronidation capacity, transplacental transfer in parturients and racemization in biological samples.

Olga Papini et al.

Journal of pharmaceutical and biomedical analysis, 40(2), 397-403 (2005-09-07)

The present study investigates the kinetic disposition with focus on the racemization, glucuronidation capacity and the transplacental transfer of lorazepam in term parturients during labor. The study was conducted on 10 healthy parturients aged 18-37 years with a gestational age

Alle zugehörigen Dokumente anzeigen

Protokolle

UHPLC/MS for Drug Detection in Urine

Optimize β-glucuronidase hydrolysis for glucuronide metabolite analysis considering factors like time, temperature, pH, and enzyme concentration.

Global Trade Item Number

SKU	GTIN
L-021-1ML	04061833945322

Questions

Reviews

No rating value

Active Filters

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung