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Buprenorphin-Glucuronid -Lösung

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(e):

Buprenorphin-3-β-D-Glucuronid -Lösung

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About This Item

Empirische Formel (Hill-System):
C35H49NO10
CAS-Nummer:
101224-22-0
Molekulargewicht:
643.76
EG-Nummer:
200-659-6
MDL-Nummer:
MFCD08275541
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329773109
NACRES:
NA.24

Qualität

certified reference material

Form

liquid

Leistungsmerkmale

SNAP-N-SPIKE®, SNAP-N-SHOOT®

Verpackung

ampule of 1 mL

Hersteller/Markenname

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland)

Konzentration

100 μg/mL in methanol

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Anwendung(en)

clinical testing

Format

single component solution

Lagertemp.

−20°C

SMILES String

CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)c7O[C@@H]2[C@]3(CCN4CC8CC8)c57

InChI

1S/C35H49NO10/c1-31(2,3)32(4,42)20-15-33-10-11-35(20,43-5)30-34(33)12-13-36(16-17-6-7-17)21(33)14-18-8-9-19(26(46-30)22(18)34)44-29-25(39)23(37)24(38)27(45-29)28(40)41/h8-9,17,20-21,23-25,27,29-30,37-39,42H,6-7,10-16H2,1-5H3,(H,40,41)/t20-,21-,23+,24+,25-,27+,29-,30-,32+,33-,34+,35-/m1/s1

InChIKey

CZULHKGIAJASAA-WWIHBJMFSA-N

Verwandte Kategorien

Allgemeine Beschreibung

Buprenorphin-Glucuronid ist ein wesentlicher Harn-Metabolit des halbsynthetischen Opioids Buprenorphin. Diese zertifizierte Dotierlösung® eignet sich für die Verwendung in LC/MS- oder GC/MS-Anwendungen in der klinischen Toxikologie, forensischen Analytik, Urin-Drogenkontrolle oder Schmerzmittelüberwachung. Buprenorphin wird zur Behandlung von mäßigen chronischen Schmerzen und bei Opioidabhängigkeit verwendet.

Anwendung


  • Simplified processing and rapid quantification of buprenorphine, norbuprenorphine, and their conjugated metabolites in human plasma using UPLC-MS/MS: This study underscores the importance of buprenorphine glucuronide as a standard in pharmacokinetic research, facilitating accurate assessments of buprenorphine exposure during opioid use disorder treatment (Zhao et al., 2024).

  • Quantitative Analysis of Buprenorphine, Norbuprenorphine, and Their Glucuronide Metabolites in Human Urine: Highlights the application of buprenorphine glucuronide in developing methods for analyzing opioid metabolites in urine, crucial for monitoring drug therapy and compliance in clinical settings (Gqamana et al., 2024).

  • Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome: The research uses buprenorphine glucuronide to study drug interactions in treating neonatal opioid withdrawal, demonstrating its significance in neonatal pharmacological research and therapy optimization (Tobacyk et al., 2023).


Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Zielorgane

Eyes

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 1

Flammpunkt (°F)

49.5 °F - closed cup

Flammpunkt (°C)

9.7 °C - closed cup

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

C W Hand et al.
British journal of anaesthesia, 64(3), 276-282 (1990-03-01)
The disposition of buprenorphine has been studied in two patient groups to assess the influence of impaired renal function on the metabolism of buprenorphine and two of its metabolites, buprenorphine-3-glucuronide (B3G) and norbuprenorphine (NorB). A single i.v. dose of 0.3
C W Hand et al.
Annals of clinical biochemistry, 23 ( Pt 1), 47-53 (1986-01-01)
Quantitative analysis of potent opiate drugs in plasma by radioimmunoassay is potentially inaccurate because of the occurrence of cross-reacting metabolites. This paper describes the chemical synthesis of buprenorphine-3-O-glucuronide, a metabolite of buprenorphine, and an extraction procedure coupled with radioimmunoassay which
Wei Huang et al.
Therapeutic drug monitoring, 28(2), 245-251 (2006-04-22)
The opioid partial agonist medication, buprenorphine (BUP), and its primary metabolite, norbuprenorphine (NBUP), are extensively glucuronidated. Sensitive analytical methods that include determination of buprenorphine-3-glucuronide (BUPG) and norbuprenorphine-3-glucuronide (NBUPG) are needed to more fully understand the metabolism and pharmacokinetics of buprenorphine.
S Hegstad et al.
Journal of analytical toxicology, 31(4), 214-219 (2007-06-09)
A liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed and validated for the determination of buprenorphine-glucuronide (BUP-G) and norbuprenorphine-glucuronide (NBUP-G) in human urine. The method included a dilution step followed by filtration through a Mini-Uniprep Filter and direct injection onto
Constance M Murphy et al.
Journal of mass spectrometry : JMS, 40(1), 70-74 (2005-01-08)
A liquid chromatographic/electrospray ionization tandem mass spectrometric method for the quantification of the synthetic opiate buprenorphine (BUP), norbuprenorphine (NBUP), buprenorphine-3-beta-D-glucuronide (BUP-3-G) and norbuprenorphine-3-beta-D-glucuronide (NBUP-3-G) in human plasma was developed and validated. Identification and quantification were based on the following transitions:
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Protokolle

UHPLC/MS for Drug Detection in Urine

Optimize β-glucuronidase hydrolysis for glucuronide metabolite analysis considering factors like time, temperature, pH, and enzyme concentration.

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