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A-096

Aldosteron

Name: Aldosteron
Brand: CERILLIAN
Price: 212 EUR

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

Synonym(e):

11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 11β,21-Dihydroxypregn-4-en-3,18,20-trion, 18-Aldocorticosteron, Reichstein X

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Packungsgröße	SKU	Verfügbarkeit	Preis
1 mL		Warenkorb auf Verfügbarkeit prüfen	€ 212,00

Über diesen Artikel

Empirische Formel (Hill-System):

C₂₁H₂₈O₅

CAS-Nummer:

52-39-1

Molekulargewicht:

360.44

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329770641

EC Number:

200-835-2

Beilstein/REAXYS Number:

3224996

MDL number:

MFCD00051136

€ 212,00

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grade

certified reference material

Quality Level

300

form

liquid

feature

SNAP-N-SPIKE^®, SNAP-N-SHOOT^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

concentration

100 μg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

General description

Aldosterone is a hormone in the mineralocorticoid family which stimulates sodium transport across cell membranes and assists in the maintenance of blood pressure and blood volume. Aldosterone levels in serum/plasma and urine are measured by LC-MS/MS for investigation of primary or secondary aldosteronism ranging from adrenal cortical hyperplasia to renovascular disease and Bartter′s syndrome.

Application

Das d-Isomer von Aldosteron wird als das biologisch aktive Isomer betrachtet.

Other Notes

Liegt in einem Gleichgewichtsgemisch aus Adehyd und Hemiacetal vor.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS02,GHS07

signalword

Danger

hcodes

H225,H302 + H312 + H332,H319

pcodes

P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Lagerklasse

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Evidence of primary aldosteronism in a predominantly female cohort of normotensive individuals: a very high odds ratio for progression into arterial hypertension.

Athina Markou et al.

The Journal of clinical endocrinology and metabolism, 98(4), 1409-1416 (2013-03-09)

Primary aldosteronism (PA) is an established cause of hypertension, whereas high-normal serum aldosterone levels have been linked to an increased risk for hypertension. We aimed to define the post-fludrocortisone-dexamethasone suppression test (FDST) normal cutoff values of aldosterone and the aldosterone

Estrogen receptor-β in the paraventricular nucleus and rostroventrolateral medulla plays an essential protective role in aldosterone/salt-induced hypertension in female rats.

Baojian Xue et al.

Hypertension (Dallas, Tex. : 1979), 61(6), 1255-1262 (2013-04-24)

The identification of the specific estrogen receptor (ER) subtypes that are involved in estrogen protection from hypertension and their specific locations in the central nervous system is critical to our understanding and design of effective estrogen replacement therapies in women.

Regulation of aldosterone secretion: from physiology to disease.

Felix Beuschlein

European journal of endocrinology, 168(6), R85-R93 (2013-04-10)

Arterial hypertension is a major cardiovascular risk factor that affects between 10 and 40% of the population in industrialized countries. Primary aldosteronism (PA) is the most common form of secondary hypertension with an estimated prevalence of around 10% in referral

Aldosterone and myocardial extracellular matrix expansion in type 2 diabetes mellitus.

Ajay D Rao et al.

The American journal of cardiology, 112(1), 73-78 (2013-04-20)

Myocardial extracellular matrix expansion and reduced coronary flow reserve (CFR) occur in patients with type 2 diabetes mellitus without heart failure or coronary artery disease. Because aldosterone is implicated in the pathophysiology of cardiac fibrosis and vascular injury, the aim

Aldosterone excess impairs first phase insulin secretion in primary aldosteronism.

Evelyn Fischer et al.

The Journal of clinical endocrinology and metabolism, 98(6), 2513-2520 (2013-03-30)

Primary aldosteronism (PA) represents the most frequent cause of secondary arterial hypertension. Conflicting data have been published regarding the effect of aldosterone excess on glucose metabolism. Our aim was to analyze insulin sensitivity and β-cell function in a cohort of

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Protokolle

LC/MS/MS Analysis of Steroid Hormones in Plasma

The conversion of clinical methods to LC/MS/MS offers advantages; however, is accompanied by a few limitations, notably interference effects from the endogenous sample matrix.

Global Trade Item Number

SKU	GTIN
A-096-1ML	04061833326336

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