T101

Gaboxadol -hydrochlorid

solid, ≥98% (HPLC)

• Synonym(e): 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride, THIP hydrochloride
• Empirische Formel (Hill-System): C₆H₈N₂O₂ · HCl
• CAS-Nummer: 85118-33-8
• Molekulargewicht: 176.60
• NACRES: NA.22
• PubChem Substance ID: 57654649
• UNSPSC Code: 12352100
• EC Number: 285-687-7
• MDL number: MFCD00055180
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white
• solubility: ethanol: 0.91 mg/mL, H₂O: 20 mg/mL
• SMILES string: Cl[H].Oc1noc2CNCCc12
• InChI: 1S/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H
• InChI key: ZDZDSZQYRBZPNN-UHFFFAOYSA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562) ;

Beschreibung

General description

Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors. Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia and Huntington′s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body.

Application

Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.

Biochem/physiol Actions

GABA_A receptor agonist.

Disclaimer

Photosensitive

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)