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931853

Sigma-Aldrich

SPhos Pd G6 acylation

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≥95%

Synonym(e):

(SPhos)Pd(4-CH2CH2CONHSPh)Br

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About This Item

Empirische Formel (Hill-System):
C39H47BrNO6PPd
CAS-Nummer:
2723495-97-2
Molekulargewicht:
843.09
MDL-Nummer:
MFCD34704619
UNSPSC-Code:
12352100
NACRES:
NA.21
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Qualitätsniveau

100

Assay

≥95%

Form

powder

Eignung der Reaktion

reagent type: catalyst
reaction type: Cross Couplings

Grünere Alternativprodukt-Eigenschaften

Catalysis
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Grünere Alternativprodukt-Kategorie

Aligned

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Allgemeine Beschreibung

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product has been enhanced for catalytic efficiency. Click here for more information.

Anwendung

SPhos Pd G6 acylation is an oxidative addition complex (OAC) of SPhos for use in bioconjugation. The pendant NHS-functional group allows coupling to protein amines through a selective acylation. The protein-OAC can then be reacted with a second, cysteine-containing protein. This facile approach allows for protein homodimerization as well as the formation of antibody-protein conjugates.

Learn more about G6 Buchwald precatalysts

Sonstige Hinweise

Palladium–Protein Oxidative Addition Complexes by Amine-Selective Acylation

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Die Dokumentenbibliothek aufrufen

Muhammad Jbara et al.
Angewandte Chemie (International ed. in English), 60(21), 12109-12115 (2021-03-18)
Organometallic reagents enable practical strategies for bioconjugation. Innovations in the design of water-soluble ligands and the enhancement of reaction rates have allowed for chemoselective cross-coupling reactions of peptides and proteins to be carried out in water. There are currently no
Heemal H Dhanjee et al.
Journal of the American Chemical Society, 142(51), 21237-21242 (2020-12-16)
Palladium oxidative addition complexes (OACs) are traditionally accessed by treating an aryl halide-containing substrate with a palladium(0) source. Here, a new strategy to selectively prepare stable OACs from amino groups on native proteins is presented. The approach relies on an
Ryan P King et al.
Organic letters, 23(20), 7927-7932 (2021-10-07)
The utilization of isolated Palladium Oxidative Addition Complexes (OACs) has had a significant impact on Pd-catalyzed and Pd-mediated cross-coupling reactions. Despite their importance, widespread utility of OACs has been limited by the instability of their precursor complexes. Herein, we report

Artikel

Buchwald G6 Precatalysts: Oxidative Addition Complexes

Buchwald G6 precatalysts are oxidative addition complexes that are thermally, air, and moisture stable. The catalyst activation doesn’t require a base and generates innocuous byproducts.

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