The AgNO3 titration is used to determine the HCl content in the molecule, and the mentioned 12.9% is indeed the HCl content.
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Pomalidomide-dipiperazine-NH2 hydrochloride
≥95%
Synonym(e):
4-(4-(4-(2-Aminoethyl)piperazine-1-carbonyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride, Crosslinker−E3 ligase ligand conjugate, Pomalidomide conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader
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50 MG
€ 402,00
About This Item
Empirische Formel (Hill-System):
C24H31N7O5 · xHCl
Molekulargewicht:
497.55 (free base basis)
UNSPSC-Code:
12352101
NACRES:
NA.22
Empfohlene Produkte
ligand
pomalidomide
Qualitätsniveau
Assay
≥95%
Form
powder
Eignung der Reaktion
reactivity: carboxyl reactive
reagent type: ligand-linker conjugate
Funktionelle Gruppe
amine
Lagertemp.
2-8°C
SMILES String
O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC=C3N4CCN(C(N5CCN(CCN)CC5)=O)CC4
InChIKey
KLJJLERZEMIGTG-UHFFFAOYSA-N
Verwandte Kategorien
Anwendung
Protein degrader building block Pomalidomide-dipiperazine-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a rigid linker, and a pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Sonstige Hinweise
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Targeted Protein Degradation by Small Molecules
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Targeted Protein Degradation by Small Molecules
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Rechtliche Hinweise
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
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Preisangaben
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Artikel
Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.
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Can the mentioned number (12.9%) be considered as the percentage of HCl, given that the amount of HCl in general is typically determined by titration? Additionally, the only test listed is "Titration with AgNO3," but it does not specify what is being titrated.
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