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Merck

901379

Sigma-Aldrich

Polyester bis-MPA dendron

no. Surface Groups 2, carboxyl, 1 NHBoc (core), generation 1

Synonym(e):

PFd-G1-BOCNH-COOH, bis-MPA dendron

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About This Item

Empirische Formel (Hill-System):
C29H47NO17
Molekulargewicht:
681.68
UNSPSC-Code:
12162002

Form

solid

Mol-Gew.

generation 1

Anzahl Oberflächengruppen

2

Farbe

white to off-white

Lagertemp.

−20°C

Allgemeine Beschreibung

  • Polymer architecture: Dendron
  • Generation: 1
  • Core functional group: Boc-protected amine
  • End Group Functionality: Carboxylic acid
  • No. Surface Groups: 2
  • Calculated Mol. Wt.: 681.69 g/mol
  • Boc: tert-Butyloxycarbonyl
  • bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid

Anwendung

Bis-MPA (or 2,2-bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. Both the carboxylic acid-functionalized dendrimers and amine-functionalized (after Boc deprotection) core can be readily used in EDC or DCC coupling reactions with amine or carbonyl-containing compounds, respectively, to yield highly functionalized materials for a variety of biomedical applications.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Artikel

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).

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