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Merck

550019

Sigma-Aldrich

N,N-Dimethyldipropylentriamin

99%

Synonym(e):

DMAPAPA

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About This Item

Lineare Formel:
(CH3)2N(CH2)3NH(CH2)3NH
CAS-Nummer:
Molekulargewicht:
159.27
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352100
PubChem Substanz-ID:
NACRES:
NA.22

Qualitätsniveau

Assay

99%

Brechungsindex

n20/D 1.4630 (lit.)

bp

220 °C (lit.)

Dichte

0.883 g/mL at 25 °C (lit.)

SMILES String

CN(C)CCCNCCCN

InChI

1S/C8H21N3/c1-11(2)8-4-7-10-6-3-5-9/h10H,3-9H2,1-2H3

InChIKey

OMKZWUPRGQMQJC-UHFFFAOYSA-N

Verwandte Kategorien

Allgemeine Beschreibung

N,N-Dimethyldipropylenetriamine is an aliphatic acyclic amine that is commonly used to develop polymeric system for gene delivery.

Anwendung

N,N-Dimethyldipropylenetriamine (DP) may be used to:
  • Prepare poly(ethylene oxide)-b-poly(3-caprolactone-g-DP) [PEO-b-P(CL-g-DP)], a biodegradable amphiphilic polycationic copolymer.
  • Develop a second generation aminoglycoside 6′-N-acetyltransferase (AAC(6′) inhibitor.
  • Prepare a hydrophilic gemcitabine conjugated cationic copolymer, which can be employed in the treatment pancreatic cancer.

Rechtliche Hinweise

Product of Arkema Inc.

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Corr. 1A - Skin Sens. 1

Lagerklassenschlüssel

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flammpunkt (°F)

210.2 °F - closed cup

Flammpunkt (°C)

99 °C - closed cup

Persönliche Schutzausrüstung

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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Die Dokumentenbibliothek aufrufen

Feng Gao et al.
Journal of medicinal chemistry, 49(17), 5273-5281 (2006-08-18)
Truncated aminoglycoside-coenzyme A bisubstrate analogues were efficiently prepared using a convergent approach where the amine and the thiol are coupled in one pot with the addition of a linker, without the need for protecting groups. These derivatives were tested for
Xiao-Bing Xiong et al.
Biomaterials, 30(2), 242-253 (2008-10-08)
The RNA interference (RNAi) technology has been successfully used in elucidating mechanisms behind various biological events. However, in the absence of safe and effective carriers for in vivo delivery of small interfering RNAs (siRNAs), application of this technology for therapeutic
Anupama Mittal et al.
Biomaterials, 35(25), 7077-7087 (2014-05-20)
Clinical effectiveness of gemcitabine in pancreatic cancer is hindered due to its rapid plasma metabolism and development of chemo-resistance. We have previously delineated the significant role of miRNAs in mediating the growth and proliferation of cancer stem cells (CSCs) which
[Toxicity of several aliphatic amines].
G I Sidorin et al.
Gigiena truda i professional'nye zabolevaniia, (11)(11), 50-53 (1984-11-01)
J Shen et al.
Biomaterials, 34(18), 4520-4531 (2013-03-23)
The low toxicity and efficient gene delivery of polymeric vectors remain the major barrier to the clinical application of non-viral gene therapy. Here, we present a poly-D, L-succinimide (PSI)-based biodegradable cationic polymer which mimicked the golden standard, branched polyethylenimine (PEI

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