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Merck

465232

Sigma-Aldrich

4-Brom-2-fluorbenzaldehyd

96%

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About This Item

Lineare Formel:
BrC6H3(F)CHO
CAS-Nummer:
Molekulargewicht:
203.01
MDL-Nummer:
UNSPSC-Code:
12352100
PubChem Substanz-ID:

Assay

96%

Form

solid

mp (Schmelzpunkt)

58-62 °C (lit.)

Funktionelle Gruppe

aldehyde
bromo
fluoro

SMILES String

Fc1cc(Br)ccc1C=O

InChI

1S/C7H4BrFO/c8-6-2-1-5(4-10)7(9)3-6/h1-4H

InChIKey

UPCARQPLANFGQJ-UHFFFAOYSA-N

Anwendung

4-Bromo-2-fluorobenzaldehyde has been used in the preparation of:
  • 2-functionalized aromatic monoaldehydes, via reaction with different secondary amines and phenol[1]
  • fluorostilbenes[2]
  • benzyl amine-based histamine H3 antagonist having serotonin reuptake activity[3]
  • 6-bromo-2-(4-bromo-2-fluorophenyl)-2,3-dihydro-4H-chromen-4-one[4]

Piktogramme

Exclamation mark

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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Die Dokumentenbibliothek aufrufen

Michael A Letavic et al.
Bioorganic & medicinal chemistry letters, 17(17), 4799-4803 (2007-07-10)
The design, synthesis, and in vitro activity of a series of novel 5-ethynyl-2-aryloxybenzylamine-based histamine H(3) ligands that are also serotonin reuptake transporters is described.
Richard J Sciotti et al.
Bioorganic & medicinal chemistry letters, 12(16), 2121-2123 (2002-07-20)
A novel series of antimicrobials of the oxazolidinone class is disclosed. These compounds are characterized relative to previously described analogues by a 'halostilbene-derived' pharmacophore and demonstrate enhanced antimicrobial activity against key Gram-positive pathogens when compared to Linezolid.
Hany F Nour et al.
Organic & biomolecular chemistry, 9(9), 3258-3271 (2011-03-25)
2-Functionalised aromatic monoaldehydes were synthesised in good to excellent yields by reacting 4-bromo-2-fluorobenzaldehyde with different secondary amines and phenol. The Suzuki-coupling reaction of the newly functionalised aromatic monoaldehydes with 4-formylphenylboronic acid afforded the corresponding 2-functionalised-4,4'-biphenyldialdehydes in good yields (47-85%). The
Simona Rapposelli et al.
Archiv der Pharmazie, 344(6), 372-385 (2011-02-15)
Aldose reductase (ARL2) is the first enzyme in the polyol pathway which catalyzes the NADPH-dependent reduction of glucose to sorbitol. Its involvement on diabetic complications makes this enzyme a challenge therapeutic target widely investigated to limit and/or prevent them. On

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