43124

1-(Diphenylmethyl)-piperazin

≥98.0% (NT)

• Synonym(e): 1-Benzhydryl-piperazin
• Empirische Formel (Hill-System): C₁₇H₂₀N₂
• CAS-Nummer: 841-77-0
• Molekulargewicht: 252.35
• Beilstein: 222773
• EG-Nummer: 212-667-7
• MDL-Nummer: MFCD00038379
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 57650151

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98.0% (NT)
• Verunreinigungen: ≤5.0% water
• SMILES String: C1CN(CCN1)C(c2ccccc2)c3ccccc3
• InChI: 1S/C17H20N2/c1-3-7-15(8-4-1)17(16-9-5-2-6-10-16)19-13-11-18-12-14-19/h1-10,17-18H,11-14H2
• InChIKey: NWVNXDKZIQLBNM-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

1-(Diphenylmethyl)piperazine is an intermediate during drug synthesis. It has been reported to be formed during the oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] in rat liver microsomes.[1] It reacts with quinone in acetonitrile, followed by oxidation with an alkaline potassium ferricyanide, to afford 4-amino-3,6-di(tert-butyl)-o-benzoquinones.[2]

Anwendung

1-(Diphenylmethyl)piperazine [N-(Diphenylmethyl)piperazine] may be used for the synthesis of 2-nitro-3,4,4-trichloro-1-(propylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene and 2-nitro-3,4,4-trichloro-1-(octadecylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene.[3]

Sicherheitshinweise

• Piktogramme: GHS06,GHS08,GHS05,GHS09
• Signalwort: Danger
• H-Sätze: H301,H317,H318,H361,H370,H372,H411
• P-Sätze: P202 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Repr. 2 - Skin Sens. 1A - STOT RE 1 - STOT SE 1
• Zielorgane: Central nervous system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type N95 (US)