394963

N,N-Dimethylformamiddimethylacetal

derivatization grade (GC derivatization), LiChropur^™

• Synonym(e): 1,1-Dimethoxy-N,N-dimethylmethylamin, 1,1-Dimethoxytrimethylamin
• Lineare Formel: (CH₃)₂NCH(OCH₃)₂
• CAS-Nummer: 4637-24-5
• Molekulargewicht: 119.16
• UNSPSC Code: 23151817
• NACRES: NA.22
• PubChem Substance ID: 24864631
• EC Number: 225-063-3
• Beilstein/REAXYS Number: 506020
• MDL number: MFCD00008482
• Assay: >95%
• Form: liquid

Eigenschaften

• grade: derivatization grade (GC derivatization)
• Quality Segment: 100
• assay: >95%
• form: liquid
• quality: LiChropur^™
• reaction suitability: reagent type: derivatization reagent; reaction type: Acylations, reagent type: derivatization reagent; reaction type: Esterifications
• technique(s): gas chromatography (GC): suitable
• refractive index: n20/D 1.396 (lit.)
• bp: 102-103 °C/720 mmHg (lit.)
• density: 0.897 g/mL at 25 °C (lit.)
• SMILES string: COC(OC)N(C)C
• InChI: 1S/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H3
• InChI key: ZSXGLVDWWRXATF-UHFFFAOYSA-N

Beschreibung

General description

Esterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters.

Application

It may be used in methylation of heterocyclic compounds which contains SH, NH, OH groups such as benzimidazole, naphth[2,3-c]imidazole, imidazo[4,5-c]-pyridine, purine, pyridine, pyrimidine, pyridazine and s-triazolo[4,3-b]pyridazine. It was used as derivatizing agent in a study to determine cocaine and benzoyl ecgonine in urine using GC with on-column alkylation.

Für die Katalyse der Kopplung von Epoxiden mit Kohlendioxid unter lösungsmittelfreien Bedingungen zu cyclischen Carbonaten.

Zur Herstellung von Formamidin-Derivaten, als Syntheseintermediate

Suitable for the derivatization of primary sulfonamides and trifluoroacetic acid.

Other Notes

Reagent for n-dimethylaminomethylene and methyl esters.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H225,H317,H318,H332
• pcodes: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Eye Dam. 1 - Flam. Liq. 2 - Skin Sens. 1
• Lagerklasse: 3 - Flammable liquids
• wgk: WGK 1
• flash_point_f: 42.8 °F
• flash_point_c: 6 °C
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter