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Dokumente

176478

Sigma-Aldrich

3-(4-Fluorbenzoyl)-propionsäure

97%

Synonym(e):

Haloperidol-Metabolit III, R 11302

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About This Item

Lineare Formel:
FC6H4COCH2CH2CO2H
CAS-Nummer:
366-77-8
Molekulargewicht:
196.18
EG-Nummer:
206-679-1
MDL-Nummer:
MFCD00002793
UNSPSC-Code:
12352100
eCl@ss:
39040324
PubChem Substanz-ID:
24850580
NACRES:
NA.22

Assay

97%

Form

solid

mp (Schmelzpunkt)

100-102 °C (lit.)

SMILES String

OC(=O)CCC(=O)c1ccc(F)cc1

InChI

1S/C10H9FO3/c11-8-3-1-7(2-4-8)9(12)5-6-10(13)14/h1-4H,5-6H2,(H,13,14)

InChIKey

WUYWHIAAQYQKPP-UHFFFAOYSA-N

Allgemeine Beschreibung

3-(4-Fluorobenzoyl)propionic acid is a metabolite of haloperidol, a dopamine D2 receptor blocker.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Sarita Forsback et al.
Synapse (New York, N.Y.), 51(2), 119-127 (2003-11-18)
In order to characterize the sensitivity of an analog of levodopa and a dopamine transporter ligand to detect defects in nigrostriatal function, the uptake of [(18)F]FDOPA and [(18)F]CFT was studied ex vivo in a rat model of Parkinson's disease. The
G A Digenis et al.
Journal of pharmaceutical sciences, 70(9), 985-989 (1981-09-01)
Tissue distribution studies of [18F]haloperidol and [82Br]bromperidol, two potent neuroleptic drugs, were performed in rats by serial sacrifice. The usefulness of external scintigraphy in obtaining tissue distribution data in large animals is demonstrated by the tissue distribution of [18F]haloperidol in
M Watanabe et al.
Xenobiotica; the fate of foreign compounds in biological systems, 29(8), 839-846 (1999-12-20)
1. The aim was to identify whether CYP3A metabolizes bromperidol (BP), an antipsychotic drug, to form 4-fluorobenzoyl-propionic acid (FBPA) in hepatic microsomes from 8-week-old male Sprague-Dawley rats and to investigate whether an inhibitor or an inducer of CYP3A affects BP
M Watanabe et al.
Fundamental & clinical pharmacology, 13(3), 337-342 (1999-07-07)
Haloperidol (HP), an antipsychotic drug, is N-dealkylated by cytochrome P450 (CYP) to 4-fluorobenzoylpropionic acid (FBPA). The purpose of this study was to identify whether CYP3A metabolizes HP to FBPA in hepatic microsomes of rats and to investigate whether an inhibitor
T Tateishi et al.
Life sciences, 67(24), 2913-2920 (2001-01-02)
We studied the biotransformation of haloperidol, bromperidol and their reduced forms by human liver microsomes. Nifedipine oxidation (CYP3A) activity correlated significantly with N-dealkylation rates of haloperidol and bromperidol and oxidation rates of their reduced forms, while neither ethoxyresorufin O-deethylation (CYP1A2)
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