10919

Fmoc-isothiocyanat

≥98.0% (CHN)

• Synonym(e): 9-Fluorenylmethoxycarbonyl-isothiocyanat, Isothiocyanatoameisensäure-9-fluorenylmethylester
• Empirische Formel (Hill-System): C₁₆H₁₁NO₂S
• CAS-Nummer: 199915-38-3
• Molekulargewicht: 281.33
• Beilstein: 7930648
• MDL-Nummer: MFCD01861169
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 57646854
• NACRES: NA.22

Eigenschaften

• Assay: ≥85% (coupling to amines); ≥98.0% (CHN)
• Löslichkeit: ethanol: soluble
• Fluoreszenz: λ_ex 264 nm; λ_em 313 nm
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: Fmoc
• Lagertemp.: −20°C
• SMILES String: O=C(OCC1c2ccccc2-c3ccccc13)N=C=S
• InChI: 1S/C16H11NO2S/c18-16(17-10-20)19-9-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15H,9H2
• InChIKey: DHMYULZVFHHEHE-UHFFFAOYSA-N

Beschreibung

Anwendung

Fmoc isothiocyanate can be used:

• As a starting material in the preparation of biologically relevant pharmacophores named N-aryl-N′-carboalkoxy guanidines.
• In one of the intermediate steps for the synthesis of N-aryl-N-thiazolyl derivatives.
• To synthesize cyclic isothiourea derivatives as potent neuropeptide Y (NPY) Y1 receptor antagonists.
• To prepare 2-aminothiazoles, aminobenz-imidazole conjugated thiazoles, and thiazole derived cyclopeptides.

Sonstige Hinweise

Reagent for the synthesis of substituted thioureas from amines

Sicherheitshinweise

• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H315,H318,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves