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P4005

Sigma-Aldrich

Protamine

solid

Sinónimos:

Protamine

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About This Item

Número de CAS:
9012-00-4
EC Number:
232-726-0
MDL number:
MFCD00132089
UNSPSC Code:
12352202
NACRES:
NA.77

product name

Protamine from salmon, Grade IV, Histone, free(Millon test)

biological source

fish (salmon)

type

Grade IV

form

solid

impurities

Histone, free (Millon test)

solubility

H2O: soluble, clear to slightly hazy, colorless to faintly yellow

storage temp.

−20°C

General description

Protamines are proteins rich in cysteine and arginine. It possesses many phosphorylation sites. Salmon fish contains around 15 genes encoding protamine. It is found to be localized to the sperm head.

Application

Protamine from salmon has been used to avoid in vitro AT complex formation in samples from dogs pre-treated with heparin. It has also been used to study the influences of external potential on adsorption of various proteins to a metal surface.

Biochem/physiol Actions

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamines are found to displace histones in DNA during spermatogenesis in animals and plants. Protamine is useful as a heparin neutralizer during heart surgery, dialysis and in many other clinical procedures.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin
Petersen LC, et al.
British Journal of Haematology, 152(1), 99-107 (2011)
Adsorption characteristics of various proteins on a metal surface in the presence of an external electric potential
Htwe EE, et al.
Colloids and Surfaces, B: Biointerfaces, 262-268 (2018)
Vanesa Lafarga et al.
The EMBO journal, 40(13), e103311-e103311 (2021-05-13)
Due to their capability to transport chemicals or proteins into target cells, cell-penetrating peptides (CPPs) are being developed as therapy delivery tools. However, and despite their interesting properties, arginine-rich CPPs often show toxicity for reasons that remain poorly understood. Using
Ryan B McMillan et al.
Biophysical journal, 120(12), 2521-2531 (2021-05-24)
DNA looping plays an important role in cells in both regulating and protecting the genome. Often, studies of looping focus on looping by prokaryotic transcription factors like lac repressor or by structural maintenance of chromosomes proteins such as condensin. Here
Alicia Roque et al.
Nucleic acids research, 32(20), 6111-6119 (2004-11-25)
Histone H1 preferentially binds and aggregates scaffold-associated regions (SARs) via the numerous homopolymeric oligo(dA).oligo(dT) tracts present within these sequences. Here we show that the mammalian somatic subtypes H1a,b,c,d,e and H1 degrees and the male germline-specific subtype H1t, all preferentially bind
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