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H7660

Sigma-Aldrich

Heregulin-β1 (EGF Domain) human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Sinónimos:

HRG-β1

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About This Item

MDL number:
MFCD03457066
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

200

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized powder

potency

<0.50 ng/mL

mol wt

predicted mol wt 8 kDa

packaging

pkg of 10 and 50 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

color

white

UniProt accession no.

Q02297

storage temp.

−20°C

Gene Information

human ... NRG1(3084)

Biochem/physiol Actions

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

Analysis Note

The biological activity is measured by its ability to stimulate the proliferation of human MCF-7 cells grown under serum-free conditions.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Neural grafts containing exosomes derived from Schwann cell-like cells promote peripheral nerve regeneration in rats.
Hu, et al.
Burns & trauma, 11, tkad013-tkad013 (2023)
Wei Tan et al.
The Journal of biological chemistry, 282(33), 24343-24351 (2007-06-15)
Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. Recently, altered expression of a novel isoform (type IV) in the brain has
Paul J Harrison et al.
Biological psychiatry, 60(2), 132-140 (2006-01-31)
Neuregulin 1 (NRG1) is a leading schizophrenia susceptibility gene. The NRG1 locus on chromosome 8p shows linkage to the disorder, and genetic association has been found between schizophrenia and various non-coding polymorphisms and haplotypes, especially at the 5' end of
Shuji Wakatsuki et al.
Genes to cells : devoted to molecular & cellular mechanisms, 19(1), 66-77 (2013-11-22)
After peripheral nerve injury, Schwann cells gain a migratory phenotype and remodel their extracellular matrix to provide a supportive environment for axonal regeneration. The soluble neuregulin-1 isoform, that is, glial growth factor (GGF), is expressed in regenerating axons of injured
A M Addington et al.
Molecular psychiatry, 12(2), 195-205 (2006-10-13)
Childhood-onset schizophrenia (COS), defined as onset of psychosis by the age of 12, is a rare and malignant form of the illness, which may have more salient genetic influence. Since the initial report of association between neuregulin 1 (NRG1) and
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