B1401
Bradykinin Fragment 1-5
≥97% (HPLC)
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1 MG
US$ 102,00
5 MG
US$ 360,00
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1 MG
US$ 102,00
5 MG
US$ 360,00
About This Item
Fórmula empírica (notación de Hill):
C27H40N8O6
Número de CAS:
Peso molecular:
572.66
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.32
Productos recomendados
Ensayo
≥97% (HPLC)
Formulario
powder
Nº de acceso UniProt
temp. de almacenamiento
−20°C
cadena SMILES
NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(O)=O
InChI
1S/C27H40N8O6/c28-18(9-4-12-31-27(29)30)24(38)35-14-6-11-21(35)25(39)34-13-5-10-20(34)23(37)32-16-22(36)33-19(26(40)41)15-17-7-2-1-3-8-17/h1-3,7-8,18-21H,4-6,9-16,28H2,(H,32,37)(H,33,36)(H,40,41)(H4,29,30,31)
Clave InChI
USSUMSBPLJWFSZ-UHFFFAOYSA-N
Información sobre el gen
human ... KNG1 (includes EG:3827)
Amino Acid Sequence
Arg-Pro-Pro-Gly-Phe
Acciones bioquímicas o fisiológicas
The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.
Envase
Bottomless glass bottle. Contents are inside inserted fused cone.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Mitsuhiro Hirata et al.
British journal of pharmacology, 135(1), 29-36 (2002-01-12)
1. The involvement of bradykinin (BK) B(2) receptor in acute pancreatitis induced by pancreaticobiliary duct ligation was investigated in rats. 2. The activities of amylase and lipase in the serum, the water content of the pancreas, and vacuolization of the
S A Doggrell
Expert opinion on investigational drugs, 10(8), 1567-1569 (2002-01-12)
When the defence response of the body to infectious bacteria fails, septic shock ensues with hypotension and death. RPPGF,(1-5)-bradykinin, was until recently considered to be an active metabolite of bradykinin. In an animal model of septicaemia (lipopolysaccharide administration to rats)
Mias Pretorius et al.
Clinical pharmacology and therapeutics, 76(4), 379-387 (2004-10-08)
This study tested the hypothesis that angiotensin-converting enzyme (ACE) inhibitors potentiate activation of the kallikrein-kinin system during cardiopulmonary bypass (CPB). The effects of CPB on concentrations of bradykinin and its metabolite bradykinin 1-5 (BK1-5) were determined in 31 patients taking
Beata Bujak-Giżycka et al.
Acta biochimica Polonica, 58(2), 199-202 (2011-05-31)
Alterations in the formation and metabolism of bradykinin (Bk) are hypothesized to play a role in the pathophysiology of hypertension, atherosclerosis and vascular complications of diabetes. However, despite its prominent role in cardiovascular regulation, studies on bradykinin have been limited
Elizabeth A Girnys et al.
Bioorganic & medicinal chemistry, 19(24), 7425-7434 (2011-11-08)
The serine protease thrombin plays several key roles in the clotting cascade within the hemostatic system, such as in fibrin formation and platelet activation. Thus, development of an inhibitor that binds to the enzyme's active site (a direct thrombin inhibitor)
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