A4487

Aphidicolin, Ready Made Solution

from Nigrospora sphaerica

• Sinónimos: ICI 69653, NSC-234714
• Fórmula empírica (notación de Hill): C₂₀H₃₄O₄
• Número de CAS: 38966-21-1
• Peso molecular: 338.48
• Número CE: 200-664-3
• Número MDL: MFCD00083214
• Código UNSPSC: 51102829
• NACRES: NA.85

Propiedades

• origen biológico: Nigrospora sphaerica
• Nivel de calidad: 200
• presión de vapor: 0.55 hPa ( 20 °C)
• Formulario: liquid
• color: clear colorless
• solubilidad: H₂O: miscible (completely)
• espectro de actividad antibiótica: neoplastics; viruses
• Modo de acción: DNA synthesis | interferes; enzyme | inhibits
• temp. de almacenamiento: −20°C
• cadena SMILES: O[C@]1([C@H]2C[C@@]3([C@@]4([C@H]([C@@]([C@@H](CC4)O)(CO)C)CC[C@H]3C2)C)CC1)CO
• InChI: 1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
• Clave InChI: NOFOAYPPHIUXJR-APNQCZIXSA-N

Descripción

Descripción general

Aphidicolin is a tetracyclic diterpene with antiviral and antimitotic properties used for cell cycle synchronization in various cell lines.[1]

Aplicación

Aphidicolin, from Nigrospora sphaerica, was used for cell cycle synchronization of tobacco BY-2 cells. It is used to block the entry of cells into S-phase.[2]

Acciones bioquímicas o fisiológicas

Aphidicolin specifically inhibits DNA polymerase α that is responsible for DNA replication. It also inhibits α-like DNA polymerases of plants and yeasts but does not inhibit synthesis of RNA and proteins. Aphidicolin competes for the dCTP-specific binding site on DNA polymerase α specifically. Aphidicolin has antiviral and antimitotic properties. It blocks the cell cycle at S phase. It has been shown to induce apoptosis in HeLa cells.[3]

Envase

1 ml

Forma física

Aphidicolin Ready Made Solution supplied as a 1 mg/ml solution in DMSO.

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 188.6 °F - closed cup
• Punto de inflamabilidad (°C): 87 °C - closed cup