As mentioned in the 'PROPERTIES' section, this product can be solubilized in chloroform at 50 mg/mL. In addition, this material is also soluble in DMSO at 5 mg/mL. DMSO stock solutions are stable for at least 6 months at -20°C. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/140/282/r7772pis.pdf
R7772
Roscovitine
≥98% (TLC)
Sinónimos:
2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
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1 MG
US$ 283,00
5 MG
US$ 981,00
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1 MG
US$ 283,00
5 MG
US$ 981,00
About This Item
Fórmula empírica (notación de Hill):
C19H26N6O
Número de CAS:
Peso molecular:
354.45
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
Productos recomendados
origen biológico
synthetic (organic)
Ensayo
≥98% (TLC)
Formulario
powder
mp
106-107 °C
solubilidad
chloroform: 50 mg/mL, clear, colorless to light yellow
temp. de almacenamiento
−20°C
cadena SMILES
CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1
InChI
1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
Clave InChI
BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Información sobre el gen
human ... CDK1(983) , CDK2(1017) , CDK5(1020) , CDK7(1022) , CDK9(1025) , CDKN1A(1026) , CDKN1B(1027) , CDKN1C(1028) , CDKN2A(1029) , CDKN2B(1030) , CDKN2C(1031) , CDKN2D(1032) , CDKN3(1033)
mouse ... CDK1(12534)
rat ... CDK1(54237)
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Categorías relacionadas
Aplicación
Roscovitine has been used:
- an inhibitor of p34cdc2/cyclin B kinase to preculture porcine oocytes[1]
- as a supplement in TCM199 medium for in vitro prematuration of cumulus-oocyte complexes (COCs) of adult goats[2]
- in astrocyte conditioned media as an inhibitor of cyclin-dependent kinase 5 (CDK5)[3]
- as a CDK2 inhibitor in culture media to treat hESCs[4]
Acciones bioquímicas o fisiológicas
Roscovitine is a potent, selective inhibitor of cyclin-dependent kinases.
Características y beneficios
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Información legal
Sold under license from CNRS
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Artículos
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
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In what solvent and at what concentration do I reconstitute Roscovitine (R7772) ?
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