Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.
Biochem/physiol Actions
Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.
Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.
Packaging
10mg, 100mg
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.
Genes encoding essential components of core cellular processes are typically highly conserved across eukaryotes. However, a small proportion of essential genes are highly taxonomically restricted; there appear to be no similar genes outside the genomes of highly related species. What
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International journal of molecular sciences, 20(24) (2019-12-15)
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