710335C

18:1 Cardiolipin

Avanti Research^™ - A Croda Brand

• Sinónimos: tetraoleoyl cardiolipin; 1,1′,2,2′-tetra-(9Z-octadecenoyl) cardiolipin (sodium salt); CL(1′-[18:1(9Z)/18:1(9Z)],3′-[18:1(9Z)/18:1(9Z)])
• Fórmula empírica (notación de Hill): C₈₁H₁₄₈O₁₇P₂Na₂
• Número de CAS: 115404-77-8
• Peso molecular: 1501.96
• Número MDL: MFCD00057815
• Código UNSPSC: 51191904
• NACRES: NA.25

Propiedades

• descripción: 1′,3′-bis[1,2-dioleoyl-sn-glycero-3-phospho]-glycerol (sodium salt), chloroform
• Ensayo: >99% (TLC)
• Formulario: solution
• envase: pkg of 1 × 2.5 mL (710335C-25mg); pkg of 2 × 4 mL (710335C-200mg); pkg of 5 × 4 mL (710335C-500mg)
• fabricante / nombre comercial: Avanti Research^™ - A Croda Brand
• concentración: 10 mg/mL (710335C-25mg); 25 mg/mL (710335C-200mg); 25 mg/mL (710335C-500mg)
• tipo de lípido: phospholipids; cardiolipins
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C

Descripción

Descripción general

Cardiolipin has two phosphatidyl residues linked by glycerol.[1] 18:1 Cardiolipin or tetraoleoyl cardiolipin (TOCL) is a monounsaturated phospholipid[2] present in mitochondria.[3] TOCL bilayers have a larger hydrocarbon chain thickness compared to dioleoyl phosphatidylcholine (DOPC) bilayer.[4]

Cardiolipin is a unique phospholipid located in the inner mitochondrial membrane,[5] which makes up to 20% of total lipids.[6] Cardiolipin is a non-bilayer anionic phospholipid, which possesses four acyl chains and a small headgroup.[7]

Cardiolipin is an anionic phospholipid.[7]

Aplicación

18:1 Cardiolipin has been used as a lipid standard in radiolabeling assay.[8]

18:1 Cardiolipin has been used for preparing solubilized lipids to assemble nanodiscs.[9][10]

18:1 Cardiolipin has been used:

• in liposome preparation for reconstituting yeast AAA ATPase protein, Msp1[11]
• in in vitro translation system for RNA transfection[10]
• as a synthetic lipid component to mimic mitochondrial inner membrane[12]

Acciones bioquímicas o fisiológicas

Cardiolipin (CL) plays a key role in coordinating energy metabolism in eukaryotes. Metabolic defect in the CL pathway is implicated in dilated cardiomyopathy.[13] CL is essential for mitochondrial functions and apoptosis.[14] Alternations in CL content and their acyl chain composition, contributes to mitochondrial dysfunction in various pathological conditions.[15]

Cardiolipin is involved in the dynamic organization of membranes and in cell division.[16] It modulates the proton uptake pathway.[7] Cardiolipin plays a critical role in mitochondrial biogenesis, fusion and fission, respiration and protein import. It controls cell wall biogenesis, vacuole homeostasis, aging, cell cycle and apoptosis.[17]

Cardiolipin participates in proton uptake pathway and also maintains the structure of enzymes involved.[7] Cardiolipin maintains the mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy.

Envase

5 mL Clear Glass Sealed Ampule (710335C-200mg)

5 mL Clear Glass Sealed Ampule (710335C-25mg)

5 mL Clear Glass Sealed Ampule (710335C-500mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• Consejos de prudencia: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Órganos de actuación: Central nervous system, Liver,Kidney
• Código de clase de almacenamiento: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): does not flash
• Punto de inflamabilidad (°C): does not flash