700172P
Avanti
cholesterol-d6
Avanti Research™ - A Croda Brand, powder
Sinónimos:
cholesterol-d6
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About This Item
Fórmula empírica (notación de Hill):
C27H40D6O
Número de CAS:
Peso molecular:
392.69
UNSPSC Code:
41141804
NACRES:
NA.25
Productos recomendados
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (700172P-10mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
Categorías relacionadas
General description
Cholesterol-d6 is a deuterium labelled cholesterol. Ring labelled D6-cholesterol forms D6-steroidal glycoalkaloids (SGA).
Cholesterol-d6 is the deuterated cholesterol with deuteration in ring.
Application
Cholesterol-d6 is suitable for its use as a synthetic lipid standard, for cholesterol determination.
Cholesterol-d6 is used as a standard to detect cholesterol concentration using chromatography technique. It is also used to measure the percentage of cholesterol absorption by intravenously administrating into experimental animals.
Cholesterol-d6 may be used as an internal standard in
- electrospray ionization tandem mass spectrometry (ESIMS/MS)
- gas chromatography–mass spectrometry (GC-MS)
- for spiking lipid extracts from Drosophila for liquid chromatography–mass spectrometry (LC-MS)
Biochem/physiol Actions
Cholesterol-d6 rich liposomes are used in understanding the kinetics of reverse cholesterol transport in lymphatic and aorta. It is used in the generation of stratum corneum (SC) lipid model systems for deuteration based neutron diffraction studies. Use of Cholesterol-d6 as a diet supplement has enabled the understanding cholesterol metabolism in the blood brain barrier.
Packaging
5 mL Amber Glass Screw Cap Vial (700172P-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
Certificados de análisis (COA)
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Guan XL, et al.
Developmental Cell, 24(1), 98-111 (2013)
Cholesterol and Other Lipid Metabolism
Stable Isotope Characterization of TICs/TIMs: Analytical Progress Report. No. LLNL-TR-413939. Lawrence Livermore National Laboratory (LLNL), Livermore, CA, 2009., 157-157 (2003)
Localisation of partially deuterated cholesterol in quaternary SC lipid model membranes: a neutron diffraction study
Kessner D, et al.
European Biophysics Journal, 37(6), 1051-1057 (2008)
Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice
Martel C, et al.
The Journal of Clinical Investigation, 123(4), 1571-1579 (2013)
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