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346357

Sigma-Aldrich

4′-(Trifluoromethyl)-2-biphenylcarboxylic acid

97%

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About This Item

Fórmula lineal:
CF3C6H4C6H4CO2H
Número de CAS:
84392-17-6
Peso molecular:
266.22
MDL number:
MFCD00075353
UNSPSC Code:
12352100
PubChem Substance ID:
24861401
NACRES:
NA.22

assay

97%

form

solid

mp

169-171 °C (lit.)

functional group

carboxylic acid
fluoro

SMILES string

OC(=O)c1ccccc1-c2ccc(cc2)C(F)(F)F

InChI

1S/C14H9F3O2/c15-14(16,17)10-7-5-9(6-8-10)11-3-1-2-4-12(11)13(18)19/h1-8H,(H,18,19)

InChI key

IQOMYCGTGFGDFN-UHFFFAOYSA-N

General description

4′-(Trifluoromethyl)-2-biphenylcarboxylic acid (xenalipin) has been tested as an effective hypolipidemic agent in animal species. It has been shown to cause significant reduction in serum cholesterol and triglyceride levels in animal models and would be beneficial in therapy for hyperlipidemia. Synthesis of 4′-(trifluoromethyl)-2-biphenylcarboxylic acid (xenalipin) has been reported. Xenalipin has been synthesized in the [14C]-labelled form, with specific activity 21.0mCi/mmol, which is suitable for the metabolism and distribution studies in animals.

Application

4′-(Trifluoromethyl)-2-biphenylcarboxylic acid may be used in chemical synthesis.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
14815EO
10728BR
04916CS
04906EA
01805LO

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M C Lewis et al.
Atherosclerosis, 64(1), 27-35 (1987-03-01)
Xenalipin (4'-trifluoromethyl-2-biphenylcarboxylic acid) is a chemically novel compound which has been found to be an effective hypolipidemic agent in two animal species. Significant reductions in serum cholesterol and triglycerides were observed in cholesterol-cholic acid-fed rats following oral doses of 10-30
Synthesis of carbon-14 labelled xenalipin-a potential hypolipidemic agent.
Hill JA and Eaddy JF.
Journal of Labelled Compounds & Radiopharmaceuticals, 31(12), 1011-1017 (1992)
The Nickel (I) Catalyzed Coupling of a Diarylzinc with an Aryl Chloride in the Synthesis of Xenalipin.
Eaddy JF.
Organic preparations and procedures international, 27(3), 367-372 (1995)

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