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860646

Sigma-Aldrich

1-Methyl-DL-tryptophan

97%

Synonym(s):

1-Methyl-DL-tryptophan, 1-Methyltryptophan, 2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid, 2-Amino-3-(1-methyl-1H-indol-3-yl)propanoicacid, 2-Amino-3-(1-methylindol-3-yl)propanoic acid, DL-1-Methyltryptophan, N′-Methyl-DL-tryptophan

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About This Item

Empirical Formula (Hill Notation):
C12H14N2O2
CAS Number:
26988-72-7
Molecular Weight:
218.25
EC Number:
248-157-6
MDL number:
MFCD00005803
UNSPSC Code:
12352100
PubChem Substance ID:
24888516
NACRES:
NA.22

Quality Level

100

Assay

97%

form

solid

mp

250 °C (dec.) (lit.)

SMILES string

Cn1cc(CC(N)C(O)=O)c2ccccc12

InChI

1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)

InChI key

ZADWXFSZEAPBJS-UHFFFAOYSA-N

Related Categories

Application

1-Methyl-DL-tryptophan, a competitive inhibitor of indoleamine 2,3 dioxygenase-1 (IDO1), has been used to study inflammation-induced depression in mice and syncytial virus induced bronchiolitis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cytotoxic T-lymphocyte-associated protein 4 immunoglobulin (CTLA4Ig) and anti-cluster of differentiation 154 (anti-CD154) are able to block B7/CD28 and CD40/CD154 co-stimulatory signals in T cells. Additionally, they promote hematopoietic stem cell transplantation (HSCT) in sensitized recipients and are able to induce
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Experimental & molecular medicine, 41(5), 315-324 (2009-03-25)
Mesenchymal stem cells (MSCs) can inhibit T cell proliferation; however, the underlying mechanisms are not clear. In this study, we investigated the mechanisms of the immunoregulatory activity of MSCs on T cells. Irradiated MSCs co-cultured with either na?ve or pre-activated
Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2, 3 dioxygenase.
Vichaya, Elisabeth G et al.
Neuropsychopharmacology (2018)
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