All Photos(3)
About This Item
Linear Formula:
(ClCH2CH2)3N·HCl
CAS Number:
Molecular Weight:
240.99
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
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Quality Level
Assay
98%
mp
127-130 °C (lit.)
SMILES string
Cl.ClCCN(CCCl)CCCl
InChI
1S/C6H12Cl3N.ClH/c7-1-4-10(5-2-8)6-3-9;/h1-6H2;1H
InChI key
VEAUDLLZYJVHRI-UHFFFAOYSA-N
Related Categories
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Oral - Carc. 2 - Skin Corr. 1B
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Landmark article Sept. 21, 1946: Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. By Louis S. Goodman, Maxwell M. Wintrobe, William Dameshek, Morton J. Goodman, Alfred Gilman and Margaret T. McLennan.
L S Goodman et al.
JAMA, 251(17), 2255-2261 (1984-05-04)
I Koza et al.
Neoplasma, 36(6), 709-718 (1989-01-01)
Fifty-three patients with advanced Hodgkin's disease, most of them previously treated, received 8 to 16 courses of modified MOPP regimens (nitrogen mustard replaced by trichlormethine in arm A, with addition of vinblastine to the 4-drug regimen in arm B, and
I Sýkora et al.
Neoplasma, 28(5), 565-574 (1981-01-01)
The cytostatic TS-160 (trichloromethine hydrochloride, tris-/2-chloroethyl/amine hydrochloride) was injected subcutaneously into SPF Wistar rats of both sexes. After all doses used, spindle-cell or even polymorphocellular sarcomas developes at the injection sites in both sexes: after the dose of 0.1 mg/kg
N I Ryabchenko et al.
General physiology and biophysics, 10(1), 41-48 (1991-02-01)
The dynamic of chromatin degradation was studied in thymocytes and LS/BL tumour cells. In permeabilised LS/BL cells, the rate of DNA degradation induced by endogenous calcium and magnesium-dependent endonuclease was approx. 25 times slower than in thymocytes. In LS/BL cells
I Sýkora et al.
Mutation research, 266(2), 291-297 (1992-04-01)
The genetic effect of the cytostatic trichlormethine hydrochloride (TS-160 Spofa) was assessed after a 1-week administration using the dominant lethal mutation test (DLM) and the sperm abnormality test. The dosage was 0.5 mg/kg for 7 consecutive days, an equivalent of
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