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15862

Sigma-Aldrich

Cobalt chloride 0.1 M solution

Synonym(s):

Cobalt(II)-chloride solution, Additive Screening Solution 24/Kit-No 78374

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About This Item

CAS Number:
7646-79-9
MDL number:
MFCD00010938
UNSPSC Code:
12352302
PubChem Substance ID:
57647530
NACRES:
NA.32

density

1.01 g/mL at 20 °C

storage temp.

2-8°C

SMILES string

Cl[Co]Cl

InChI

1S/2ClH.Co/h2*1H;/q;;+2/p-2

InChI key

GVPFVAHMJGGAJG-UHFFFAOYSA-L

Application

Cobalt chloride 0.1M solution has been used to simulate hypoxic exposure and HIF-1 (hypoxia-inducible factor 1) expression in prostate cancer cells. It has been used to induce hypoxia in human intestinal epithelial cells.

Biochem/physiol Actions

Cobalt chloride induces hypoxia condition in cells by upregulating hypoxia-inducible factor-1α (HIF-1α), erythropoietin and glycolytic enzymes. It is also responsible for mitochondrial DNA damage in rat neuronal PC12 cells. It is also responsible for the induction of apoptosis.
Cobalt chloride 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.

Pictograms

Health hazardEnvironment
GHS08,GHS09

Signal Word

Danger

Hazard Statements

H350,H360F,H411

Hazard Classifications

Aquatic Chronic 2 - Carc. 1B - Repr. 1B

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells.
Wang G, et al.
Nucleic Acids Research, 28, 2135-2135 (2000)
CoCl(2) induces apoptosis via the 18 kDa translocator protein in U118MG human glioblastoma cells.
Zeno S, et al.
Biochemistry, 48, 4652-4652 (2009)
Francesca Lazzara et al.
Frontiers in pharmacology, 11, 1063-1063 (2020-08-28)
Retinal hypoxia is one of the causative factors of diabetic retinopathy and is also one of the triggers of VEGF release. We hypothesized that specific dysregulated miRNAs in diabetic retinopathy could be linked to hypoxia-induced damage in human retinal endothelial
Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans.
Wojtal KA, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 307, G673-G673 (2014)
Mengxin Lu et al.
Cell death & disease, 9(10), 1046-1046 (2018-10-14)
Cold-inducible RNA binding protein (CIRBP) has been reported to be associated with distinct tumorigenesis. In this study, we investigated the role of CIRBP in human bladder cancer (BCa), indicating that CIRBP is overexpressed in BCa tissues and cell lines to
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