This IC50 for this compound has not been determined. A brief search of the literature shows a fairly broad range in various organisms and/or tissue types. A more thorough literature search would be advised.
A3085
5-(N-Ethyl-N-isopropyl)amiloride
≥98% (TLC), powder, Na⁺/H⁺ antiport inhibitor
Synonym(s):
EIPA
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About This Item
Empirical Formula (Hill Notation):
C11H18ClN7O
CAS Number:
Molecular Weight:
299.76
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Product Name
5-(N-Ethyl-N-isopropyl)amiloride,
biological source
synthetic
Quality Level
Assay
≥98% (TLC)
form
powder
mp
202-205 °C (lit.)
solubility
methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow
storage temp.
2-8°C
SMILES string
CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
InChI
1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChI key
QDERNBXNXJCIQK-UHFFFAOYSA-N
Gene Information
human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548) , SLC9A5(6553)
mouse ... Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278)
rat ... Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782) , Slc9a2(24783) , Slc9a3(24784) , Slc9a4(24785)
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Application
5-(N-Ethyl-N-isopropyl)amiloride has been used:
- as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cell[1]
- in Pluronic F-127 stock solution for Drosophila larval live-imaging[2]
- in choline chloride solution as an experimental perfusate, to study the effect of Na+/H+ inhibition on jejunal loop perfusion in vivo[3]
Biochem/physiol Actions
Selective blocker of Na+/H+ antiport
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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¿Cuál es el IC50 de esta sustancia?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How can I store a solution of 5-(N-Ethyl-N-isopropyl)amiloride, Product A3085?
1 answer-
We do not have solution stability information for 5-(N-Ethyl-N-isopropyl)amiloride. The product is sensitive to light, particularly in solution. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
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What concentration of Product A3085, 5-(N-Ethyl-N-isopropyl)amiloride, should I use in my experiment?
1 answer-
We have the following references for the use of 5-(N-Ethyl-N-isopropyl)amiloride. A review article mentions the use of EIPA at 1 micromolar to probe Na+ channels in rat alveolar epithelial cells; see: Matalon, S., et al., Biophysical and molecular properties of amiloride-inhibitable Na+ channels in alveolar epithelial cells. Am. J. Physiol., 271, L1-L22 (1996). A study of the effects of EIPA on infarction in isolated rabbit hearts and cardiomyocytes has been reported; see: Sato, H., et al., The mechanism of protection from 5 (N-ethyl-N-isopropyl)amiloride differs from that of ischemic preconditioning in rabbit heart. Basic Res. Cardiol., 92, 339-350 (1997).
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What can I use to make a solution of 5-(N-Ethyl-N-isopropyl)amiloride, Product A3085?
1 answer-
We test solubility of 5-(N-Ethyl-N-isopropyl)amiloride in methanol (10 mg/mL), yielding a clear yellow solution. It is also soluble in DMSO, and in dilute aqueous acid. It is insoluble in water.
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