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Anti-ZEB1 antibody produced in rabbit

Name: Anti-ZEB1 antibody produced in rabbit
Brand: SIGMA
Price: 580 USD

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-AREB6, Anti-BZP, Anti-TCF8, Anti-Zinc finger E-box binding homeobox 1

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Pack Size	SKU	Availability	Price
100 μg		Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)	$580.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), ICC, IF, IHC, WB

Citations:

$580.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

A recombinant, preservative-free antibody is available for your target. Try ZRB1129

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Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 124 kDa

species reactivity

human

technique(s)

immunocytochemistry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

CAI12550

UniProt accession no.

P37275

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ZEB1(6935)

Description

General description

Zinc finger E-box-binding homeobox 1 (ZEB1) is an EMT (epithelial-mesenchymal transition) transcription factor. The gene encoding this protein is localized on human chromosome 10p11.2.

Immunogen

ZEB1 antibody was raised against a 15 amino acid peptide near the center of human ZEB1.

The immunogen is located within amino acids 530 - 580 of ZEB1.

Application

Anti-ZEB1 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Zinc finger E-box-binding homeobox 1 (ZEB1) controls the expression of E-cadherin as a repressor. It plays an important role in tumor invasion and metastasis. Epigenetic suppression of ZEB1 might be a useful tool for overcoming drug resistance in human breast cancer. Mutations in this gene are associated with posterior polymorphous corneal dystrophy and Fuchs′ endothelial corneal dystrophy (FECD6).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500514.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB5700810	HPA027524	E3406
Sigma-Aldrich SAB3500514 Anti-ZEB1 antibody produced in rabbit	Sigma-Aldrich SAB5700810 Anti-ZEB1 antibody produced in rabbit	Sigma-Aldrich HPA027524 Anti-ZEB1 antibody produced in rabbit	Sigma-Aldrich E3406 Anti-EB1 antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
UniProt accession no. P37275	UniProt accession no. P37275	UniProt accession no. P37275	UniProt accession no. Q15691
technique(s) immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable, immunofluorescence: suitable, indirect ELISA: suitable	technique(s) immunofluorescence: 1:50-1:200, immunohistochemistry: 1:50-1:200, western blot: 1:500-1:2000	technique(s) ChIP: 1—10 μg (per reaction), immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:500-1:1000	technique(s) immunoprecipitation (IP): 10-20 μg using cell lysate of the human epitheloid carcinoma HeLa cell line, indirect immunofluorescence: 1-2 μg/mL using rat fibroblast Rat1 cells, indirect immunofluorescence: suitable, western blot: 0.5-1 μg/mL using cell lysate of the rat fibroblast cell line Rat1 or Rat 2

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

58251003

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Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling.

Jorge A

Cellular and molecular gastroenterology and hepatology (2015)

GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification.

Chung VY

Scientific Reports (2016)

An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer.

Qin Y

Oncotarget (2016)

View All Related Papers

Global Trade Item Number

SKU	GTIN
SBP3500514-0.05MG	04061832169941
SAB3500514-100UG	04061837873867

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