Key Documents

Anti-LIMP2 antibody produced in rabbit

Name: Anti-LIMP2 antibody produced in rabbit
Brand: SIGMA
Price: 584 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CD36L2, Anti-Lysosomal integral membrane protein 2, Anti-SCARB2, Anti-SR-B2, Anti-Scavenger receptor class B member 2

Select a Size

Change View

Pack Size	SKU	Availability	Price
100 μg		Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)	$584.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, WB

Citations:

$584.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 53 kDa

species reactivity

mouse, rat, human

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

AAH21892

UniProt accession no.

Q14108

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SCARB2(950)

Description

General description

Lysosomal integral membrane protein type 2 (LIMP2) is an N-glycosylated type III transmembrane protein. It is composed of a lumenal domain, two transmembrane domains, and a cytoplasmic domain. LIMP2 belongs to the CD36 family of scavenger receptor proteins and is found abundantly in the lysosome. The LIMP2 gene is located on the human chromosome at 4q21.1.

Immunogen

LIMP2 antibody was raised against a 16 amino acid peptide from near the center of human LIMP2.

Application

Anti-LIMP2 antibody produced in rabbit has been used in immunofluorescence (1:100) and western blotting.[1]

Biochem/physiol Actions

Lysosomal integral membrane protein type 2 (LIMP2) binds to β-glucocerebrosidase. Mutations in the LIMP 2 gene are associated with action myoclonus-renal failure syndrome, a fatal autosomal recessive disorder. Higher levels of LIMP2 lead to enlargement of early or late endosomes/lysosomes. Overexpression of LIMP2 is associated with impairment of endocytotic membrane trafficking.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500449.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	L1418	HPA018014	SAB3500285
Sigma-Aldrich SAB3500449 Anti-LIMP2 antibody produced in rabbit	Sigma-Aldrich L1418 Anti-LAMP1 antibody produced in rabbit	Sigma-Aldrich HPA018014 Anti-SCARB2 antibody produced in rabbit	Sigma-Aldrich SAB3500285 Anti-LAMP-1 antibody produced in rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
UniProt accession no. Q14108	UniProt accession no. P11279	UniProt accession no. Q14108	UniProt accession no. P11279
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous glycerol solution	form buffered aqueous solution

Still not finding the right product?

Try our Product Selector Tool to narrow your options

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

46210802

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-glucocerebrosidase.

Judith Blanz et al.

Human molecular genetics, 19(4), 563-572 (2009-11-26)

Action myoclonus-renal failure syndrome (AMRF) is caused by mutations in the lysosomal integral membrane protein type 2 (LIMP-2/SCARB2). LIMP-2 was identified as a sorting receptor for beta-glucocerebrosidase (beta-GC), which is defective in Gaucher disease. To date, six AMRF-causing mutations have

LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase.

Reczek, et al.

Cell, 131, 770-783 (2017)

Progressive myoclonus epilepsy without renal failure in a Chinese family with a novel mutation in SCARB2 gene and literature review.

Wo-Tu Tian et al.

Seizure, 57, 80-86 (2018-04-02)

To describe the clinical and genetic features of a Chinese progressive myoclonus epilepsy (PME) patient related with SCARB2 mutation without renal impairment and review 27 SCARB2-related PME patients from 11 countries. The patient was a 27-year-old man with progressive action

View All Related Papers

Global Trade Item Number

SKU	GTIN
SBP3500449-0.05MG	04061832169453
SAB3500449-100UG	04061832496214

Questions

Reviews

No rating value