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Anti-RUNX1 antibody produced in rabbit

Name: Anti-RUNX1 antibody produced in rabbit
Brand: SIGMA
Price: 584 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-AML1, Anti-AMLCR1, Anti-CBFA2, Anti-EVI-1, Anti-Runt-related transcription factor 1

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Pack Size	SKU	Availability	Price
100 μg		Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)	$584.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD07370485

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), WB

Citations:

$584.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

A recombinant, preservative-free antibody is available for your target. Try ZRB1936

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Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

technique(s)

indirect ELISA: suitable, western blot: suitable

NCBI accession no.

AAI36381

UniProt accession no.

Q01196

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RUNX1(861)

Description

General description

Runt-related transcription factor 1 (RUNX1) is a transcription factor that plays a crucial role in hematopoiesis, osteogenesis and neurogenesis. It is a member of Runt-related transcription factors (RUNXs). It was first identified as a component of Polyomavirus enhancer binding protein 2 (PEBP2) and Moloney murine leukemia virus enhancer core binding factor (CBF). Three isoforms of the protein have been identified: RUNX1a, RUNX1b and RUNX1c.[1]

Application

RUNX1 antibody was raised against a 16 amino acid peptide from near the center of human RUNX1.

Biochem/physiol Actions

RUNX1 (Runt-related transcription factor 1) plays a vital role in tumour suppression and oncogenic activities.[1] In hematopoiesis, it is involved in hematopoietic development, hematopoietic stem cell homeostasis, and various blood malignancies. It may have clinicopathological impact on the proliferation of human bone marrow cells used in transplantation therapy.[3]

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500417.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

1 of 1

This Item	SAB4300709	AV38073	HPA004176
Sigma-Aldrich SAB3500417 Anti-RUNX1 antibody produced in rabbit	Sigma-Aldrich SAB4300709 Anti-RUNX1 antibody produced in rabbit	Sigma-Aldrich AV38073 Anti-RUNX1 antibody produced in rabbit	Sigma-Aldrich HPA004176 Anti-RUNX1 antibody produced in rabbit
Quality Level 100	Quality Level 100	Quality Level -	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
technique(s) indirect ELISA: suitable, western blot: suitable	technique(s) western blot: 1:500-1:1000	technique(s) western blot: suitable	technique(s) immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:50-1:200
shipped in dry ice	shipped in wet ice	shipped in wet ice	shipped in wet ice

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

51490902

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Expression of RUNX1 correlates with poor patient prognosis in triple negative breast cancer.

Nicola Ferrari et al.

PloS one, 9(6), e100759-e100759 (2014-06-27)

The RUNX1 transcription factor is widely recognised for its tumour suppressor effects in leukaemia. Recently a putative link to breast cancer has started to emerge, however the function of RUNX1 in breast cancer is still unknown. To investigate if RUNX1

RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.

Kentson Lam et al.

Frontiers in bioscience (Landmark edition), 17, 1120-1139 (2011-12-29)

RUNX1 is a transcription factor that regulates critical processes in many aspects of hematopoiesis. RUNX1 is also integral in defining the definitive hematopoietic stem cell. In addition, many hematological diseases like myelodysplastic syndrome and myeloproliferative neoplasms have been associated with

Global Trade Item Number

SKU	GTIN
SBP3500417-0.05MG	04061832161648
SAB3500417-100UG	04061832496009

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