PRS4053

Anti-VISA (ab1) antibody produced in rabbit

Name: Anti-VISA (ab1) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CARD adapter inducing interferon-beta, Anti-MAVS, Anti-Mmitochondrial antiviral signaling protein, Anti-Virus-induced signaling adapter

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, WB

Citations:

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, rat

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

Q7Z434

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAVS(57506)

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This Item	SAB2900292	HPA049850	SAB1400655
Sigma-Aldrich PRS4053 Anti-VISA (ab1) antibody produced in rabbit	Sigma-Aldrich SAB2900292 Anti-VISA (AB1) antibody produced in rabbit	Sigma-Aldrich HPA049850 Anti-MAVS antibody produced in rabbit	$Anti-VISA antibody produced in mouse IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich SAB1400655 Anti-VISA antibody produced in mouse
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form IgG fraction of antiserum
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous glycerol solution	form buffered aqueous solution
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal

General description

VISA (virus-induced signalling adaptor) is also designated as MAVS (mitochondrial antiviral signalling protein). It has 540 amino acids and three main domains such as N-terminal caspase recruitment and activation domain (CARD), an internal proline-rich region and a C-terminal transmembrane (TM) domain. It is mapped to chromosome 20p13. It is intermediately expressed in all tissues and brain regions except in fetal brain.

Immunogen

a 13 amino acid peptide from near the amino-terminus of human VISA.

Biochem/physiol Actions

VISA (virus-induced signalling adaptor) serves as an adaptor molecule for retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs). It activates intracellular signaling cascades, that leads to nuclear translocation of the transcription factors- IRF3 (interferon regulatory factor 3), IRF7 (interferon regulatory factor 7), and NF-κB (Nuclear factor-κB). It also helps in the formation of type I interferons (IFN-I) and proinflammatory cytokines.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP4053.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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related product

Product No.

Description

Pricing

SBP4053

VISA (AB1) Blocking Peptide for PRS4053

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

40530604

4053-0604

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VISA--a pass to innate immunity

Qi B, et al.

The International Journal of Biochemistry & Cell Biology, 39(2), 287-291 (2007)

Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus

Zhang LK, et al.

Journal of Virology, 90(22), 10259-10270 (2016)

Alteration of Antiviral Signalling by Single Nucleotide Polymorphisms (SNPs) of Mitochondrial Antiviral Signalling Protein (MAVS)

Xing F, et al.

PLoS ONE, 11(3) (2016)

Ling Xu et al.

Journal of immunology (Baltimore, Md. : 1950), 205(8), 2091-2099 (2020-09-11)

Hepatitis C virus (HCV) infection is the cause of severe liver disease in many people. The restricted species tropism of HCV hinders the research and development of drugs and vaccines. The Chinese tree shrew (Tupaia belangeri chinensis) is a close

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