Key Documents

Anti-Caspase-1 (ab1) antibody produced in rabbit

Name: Anti-Caspase-1 (ab1) antibody produced in rabbit
Brand: SIGMA
Price: 529 USD

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Caspase 1, apoptosis-related cysteine peptidase (Interleukin 1, beta, convertase), Anti-ICE, Anti-IL-1β converting enzyme

Select a Size

Change View

Pack Size	SKU	Availability	Price
100 μg		Check Cart for Availability	$529.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.43

MDL number:

MFCD00283496

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, WB

Citations:

$529.00

Check Cart for Availability

A recombinant, preservative-free antibody is available for your target. Try ZRB1563

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

P29466

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CASP1(834)

Description

General description

Caspase-1 is also known as interleukin-1β converting enzyme (ICE). It is located on chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. It is present in leukocytes, monocytes and epithelial cells.

Immunogen

a 16 amino acid peptide from near the carboxy-terminus of human Caspase-1.

Application

Anti-Caspase-1 (ab1) antibody produced in rabbit has been used in western blotting and immunofluorescence staining.

Biochem/physiol Actions

Caspase-1 can transform the pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18 into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients. It helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3459.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	PRS3463	WH0000834M1	SAB5700660
Sigma-Aldrich PRS3459 Anti-Caspase-1 (ab1) antibody produced in rabbit	Sigma-Aldrich PRS3463 Anti-Caspase-1 (ab2) antibody produced in rabbit	Sigma-Aldrich WH0000834M1 Monoclonal Anti-CASP1 antibody produced in mouse	Sigma-Aldrich SAB5700660 Anti-Caspase 1 antibody produced in rabbit
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source rabbit	biological source mouse	biological source rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody
Gene Information human ... CASP1(834)	Gene Information human ... CASP1(834)	Gene Information human ... CASP1(834)	Gene Information human ... CASP1(834)
UniProt accession no. P29466	UniProt accession no. P29466	UniProt accession no. P29466	UniProt accession no. P29466

Still not finding the right product?

Try our Product Selector Tool to narrow your options

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

34591503

34590501

3459-0501

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (bpV(phen)) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes.

Qi Chen et al.

The Journal of biological chemistry, 290(43), 26051-26058 (2015-09-13)

Autophagy is a cellular process that controls and executes the turnover of dysfunctional organelles and misfolded or abnormally aggregated proteins. Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) activates the initiation of autophagy. Autophagosomes migrate along acetylated microtubules to

Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1

Shamaa OR, et al.

PLoS ONE, 10(11) (2015)

Defects in MAP1S-mediated autophagy turnover of fibronectin cause renal fibrosis.

Guibin Xu et al.

Aging, 8(5), 977-985 (2016-05-30)

Excessive deposition of extracellular matrix proteins in renal tissues causes renal fibrosis and renal function failure. Mammalian cells primarily use the autophagy-lysosome system to degrade misfolded/aggregated proteins and dysfunctional organelles. MAP1S is an autophagy activator and promotes the biogenesis and

View All Related Papers

Global Trade Item Number

SKU	GTIN
SBP3459-0.05MG	04061832166032
PRS3459-100UG	04061836687045

Questions

Reviews

No rating value