PRS3197

Anti-Caspase-12 (small) antibody produced in rabbit

Name: Anti-Caspase-12 (small) antibody produced in rabbit
Brand: SIGMA
Price: 580 USD

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Caspase 12

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100 μG

$580.00

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03454855

Key Documents

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Product Name

Anti-Caspase-12 (small) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 46 kDa

species reactivity

mouse, human, rat

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

O08736

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

mouse ... Casp12(12364)

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Show Differences

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This Item	PRS2245	PRS3463	SAB3500405
Sigma-Aldrich PRS3197 Anti-Caspase-12 (small) antibody produced in rabbit	Sigma-Aldrich PRS2245 Anti-Caspase-13 antibody produced in rabbit	Sigma-Aldrich PRS3463 Anti-Caspase-1 (ab2) antibody produced in rabbit	Sigma-Aldrich SAB3500405 Anti-Caspase-9 antibody produced in rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

Biochem/physiol Actions

Caspase-12 (CASP12) plays an important role in endoplasmic reticulum (ER)-related apoptosis. It moderates hepatocyte apoptosis prompted by carbon tetrachloride. Lack of caspase-12 (CASP12) increases cytokine responses.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Caspase-12 (CASP12) is an immunomodulatory factor, that is present in the cytoplasmic side of the ER (endoplasmic reticulum). It is upregulated highly in muscle, liver and kidney.

Immunogen

a synthetic peptide corresponding to amino acids within the small cleavage product of murine caspase-12.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3197.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

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Description

Pricing

SBP3197

Caspase-12 Blocking Peptide (Small) for PRS3197

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

31970501

31970404

3197-0404

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Caspase-12 deficiency enhances cytokine responses but does not protect against lethal Plasmodium yoelii 17XL infection

Miu J, et al.

Parasite Immunology, 32(11-12), 773-778 (2010)

The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity in vitro

Liu LQ, et al.

Alcoholism, Clinical and Experimental Research, 38(3), 683-693 (2014)

Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice

Liu H, et al.

World Journal of Gastroenterology, 20(48), 18189-18198 (2014)

Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance

Skeldon AM, et al.

Journal of Immunology, 196(1), 437-447 (2016)

IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivation.

Juan Carlos Gómora-García et al.

Cell death discovery, 7(1), 131-131 (2021-06-05)

Altered protein homeostasis is associated with neurodegenerative diseases and acute brain injury induced under energy depletion conditions such as ischemia. The accumulation of damaged or unfolded proteins triggers the unfolded protein response (UPR), which can act as a homeostatic response

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