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Anti-Caspase-12 (small) antibody produced in rabbit

Name: Anti-Caspase-12 (small) antibody produced in rabbit
Brand: SIGMA
Price: 580 USD

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Caspase 12

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Pack Size	SKU	Availability	Price
100 μg		Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)	$580.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03454855

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IHC, WB

Citations:

$580.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

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Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 46 kDa

species reactivity

mouse, human, rat

technique(s)

immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

O08736

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Casp12(12364)

Description

General description

Caspase-12 (CASP12) is an immunomodulatory factor, that is present in the cytoplasmic side of the ER (endoplasmic reticulum). It is upregulated highly in muscle, liver and kidney.

Immunogen

a synthetic peptide corresponding to amino acids within the small cleavage product of murine caspase-12.

Biochem/physiol Actions

Caspase-12 (CASP12) plays an important role in endoplasmic reticulum (ER)-related apoptosis. It moderates hepatocyte apoptosis prompted by carbon tetrachloride. Lack of caspase-12 (CASP12) increases cytokine responses.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3197.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	PRS2325	PRS3195	C8487
Sigma-Aldrich PRS3197 Anti-Caspase-12 (small) antibody produced in rabbit	Sigma-Aldrich PRS2325 Anti-CASPASE-12 (ab1) antibody produced in rabbit	Sigma-Aldrich PRS3195 Anti-Caspase-12 (large) antibody produced in rabbit	$Anti-Caspase 3, Active antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich C8487 Anti-Caspase 3, Active antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form IgG fraction of antiserum
technique(s) immunohistochemistry: suitable, western blot: suitable, indirect ELISA: suitable	technique(s) immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable	technique(s) immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable	technique(s) indirect immunofluorescence: 1:1,000 using human epitheloid carcinoma HeLa cell line, treated with staurosporine, microarray: suitable, western blot: 1:500 using recombinant human caspase 3, active (Sigma Product No. C1224)
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

31970501

31970404

3197-0404

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Caspase-12 deficiency enhances cytokine responses but does not protect against lethal Plasmodium yoelii 17XL infection

Miu J, et al.

Parasite Immunology, 32(11-12), 773-778 (2010)

The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity in vitro

Liu LQ, et al.

Alcoholism, Clinical and Experimental Research, 38(3), 683-693 (2014)

Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice

Liu H, et al.

World Journal of Gastroenterology, 20(48), 18189-18198 (2014)

View All Related Papers

Global Trade Item Number

SKU	GTIN
SBP3197-0.05MG	04061832179933
PRS3197-100UG	04061832509549

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