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Anti-ULK2 antibody produced in rabbit

Name: Anti-ULK2 antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Ulk2 Antibody, Ulk2 Antibody - Anti-ULK2 antibody produced in rabbit, Anti-Unc-51 like kinase 2, Anti-Unc51.2

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

This product is discontinued. Contact Technical Servicefor assistance.

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~130 kDa

species reactivity

mouse

concentration

~1.0 mg/mL

technique(s)

western blot: 2.5-5.0 μg/mL using whole extracts of HEK-293T cells expressing mouse ULK2

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This Item	HPA059507	SAB4500156	SAB4500192
Sigma-Aldrich U8008 Anti-ULK2 antibody produced in rabbit	Sigma-Aldrich HPA059507 Anti-CLK2 antibody produced in rabbit	Sigma-Aldrich SAB4500156 Anti-PLK2 antibody produced in rabbit	Sigma-Aldrich SAB4500192 Anti-TLK2 antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information human ... ULK2(9706) mouse ... Ulk2(29869) rat ... Ulk2(303206)	Gene Information human ... CLK2(1196)	Gene Information human ... PLK2(10769)	Gene Information human ... TLK2(11011)
technique(s) western blot: 2.5-5.0 μg/mL using whole extracts of HEK-293T cells expressing mouse ULK2	technique(s) immunofluorescence: 0.25-2 μg/mL	technique(s) ELISA: 1:40000, western blot: 1:500-1:1000	technique(s) ELISA: 1:5000, western blot: 1:500-1:1000
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

General description

Uncoordinated family member (unc)-51 like autophagy activating kinase 2 (ULK2) is encoded by the gene mapped to mouse chromosome 11. Mouse ULK2 (mULK2) belongs to the UNC-51-like protein kinase family. mULK2 protein is characterized with an amino-terminal kinase domain, a central proline/serine rich (PS) domain and a carboxy-terminal (C) domain. ULK2 is ubiquitously expressed and is mainly localized to autophagosomal membranes in mammalian cells.

Application

Anti-ULK2 antibody produced in rabbit has been used in western blot analysis and immunohistochemistry.

Biochem/physiol Actions

Uncoordinated family member (unc)-51 like autophagy activating kinase 2 (ULK2) plays a crucial role in autophagy. It is also implicated in the regulation of elemental biological processes conserved among wide variety of species. Downregulated expression of the gene increases astrocyte transformation and tumor growth.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number

097M4866V

116M4766V

108K4773

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The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy

Lee EJ and Tournier C

Autophagy, 7, 689-695 (2011)

Ammonia-induced autophagy is independent of ULK1/ULK2 kinases.

Cheong H

Proceedings of the National Academy of Sciences of the USA, 108, 11121-11126 (2011)

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

Nazio F

Nature Cell Biology, 15, 406-416 (2013)

Autophagy and lysosomal related protein expression patterns in human glioblastoma

Giatromanolaki A

Cancer Biology & Therapy, 15, 1468-1478 (2014)

Methylation Silencing of ULK2, an Autophagy Gene, Is Essential for Astrocyte Transformation and Tumor Growth

Shukla S

The Journal of Biological Chemistry, 289, 22306-22318 (2014)

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Global Trade Item Number

SKU	GTIN
U8008-200UL	04061838038098

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